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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 6, 2025; 13(34): 111732
Published online Dec 6, 2025. doi: 10.12998/wjcc.v13.i34.111732
Published online Dec 6, 2025. doi: 10.12998/wjcc.v13.i34.111732
Correlation between concentrations of NAMPT and NMNAT1 and the risk of upper respiratory infections in the island reef
Guo-Feng Gao, Jiao Yu, Department of Hepatology, Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai 200438, China
Sui-Yi Liu, Department of Medical Engineering, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai 200438, China
Author contributions: Liu SY designed and conducted the study; Gao GF contributed to the analysis and wrote the paper; Yu J collected the data; All authors have read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Shanghai Eastern Hepatobiliary Surgery Hospital (approval No. EHBHKY2022-H064-P001).
Informed consent statement: The study protocol was in accordance with the ethical guidelines of the 1975 Declaration of Helsinki. All patients provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement—checklist of items—and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement:
Dataset available from the corresponding author at liusuiyi81@126.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sui-Yi Liu, Chief, Department of Medical Engineering, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Medical University, No. 225 Changhai Road, Yangpu District, Shanghai 200438, China. liusuiyi81@126.com
Received: July 11, 2025
Revised: September 14, 2025
Accepted: November 18, 2025
Published online: December 6, 2025
Processing time: 146 Days and 22.5 Hours
Revised: September 14, 2025
Accepted: November 18, 2025
Published online: December 6, 2025
Processing time: 146 Days and 22.5 Hours
Core Tip
Core Tip: This study investigated the correlation between five common respiratory pathogens in the ship environment (influenza H1N1 virus, influenza B virus, Streptococcus pneumoniae, adenovirus, and severe acute respiratory syndrome coronavirus 2) and the severity of upper respiratory tract infections in patients, as well as serum concentrations of nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide nucleotide adenylyltransferase 1 (NMNAT1). We analyzed the feasibility of using NAMPT and NMNAT1 concentrations as potential biomarkers for assessing the severity of upper respiratory tract infections, providing a basis for clinical diagnosis and treatment of personnel stationed on ships and islands.