Gao GF, Yu J, Liu SY. Correlation between concentrations of NAMPT and NMNAT1 and the risk of upper respiratory infections in the island reef. World J Clin Cases 2025; 13(34): 111732 [DOI: 10.12998/wjcc.v13.i34.111732]
Corresponding Author of This Article
Sui-Yi Liu, Chief, Department of Medical Engineering, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Medical University, No. 225 Changhai Road, Yangpu District, Shanghai 200438, China. liusuiyi81@126.com
Research Domain of This Article
Infectious Diseases
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Observational Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 6, 2025 (publication date) through Dec 9, 2025
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Publication Name
World Journal of Clinical Cases
ISSN
2307-8960
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Gao GF, Yu J, Liu SY. Correlation between concentrations of NAMPT and NMNAT1 and the risk of upper respiratory infections in the island reef. World J Clin Cases 2025; 13(34): 111732 [DOI: 10.12998/wjcc.v13.i34.111732]
Correlation between concentrations of NAMPT and NMNAT1 and the risk of upper respiratory infections in the island reef
Guo-Feng Gao, Jiao Yu, Sui-Yi Liu
Guo-Feng Gao, Jiao Yu, Department of Hepatology, Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai 200438, China
Sui-Yi Liu, Department of Medical Engineering, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai 200438, China
Author contributions: Liu SY designed and conducted the study; Gao GF contributed to the analysis and wrote the paper; Yu J collected the data; All authors have read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Shanghai Eastern Hepatobiliary Surgery Hospital (approval No. EHBHKY2022-H064-P001).
Informed consent statement: The study protocol was in accordance with the ethical guidelines of the 1975 Declaration of Helsinki. All patients provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement—checklist of items—and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement:
Dataset available from the corresponding author at liusuiyi81@126.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sui-Yi Liu, Chief, Department of Medical Engineering, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Medical University, No. 225 Changhai Road, Yangpu District, Shanghai 200438, China. liusuiyi81@126.com
Received: July 11, 2025 Revised: September 14, 2025 Accepted: November 18, 2025 Published online: December 6, 2025 Processing time: 146 Days and 22.5 Hours
Abstract
BACKGROUND
The frequent occurrence of respiratory diseases in the island reef environment of the navy severely affects the health of personnel and the combat effectiveness of the troops. Current common screening methods can only indicate whether there is an infection with pathogenic microorganisms but not the degree of disease progression. Therefore, it is necessary to identify simple-to-operate and cost-effective methods that indicate the degree of disease progression, based on traditional screening methods.
AIM
To explores correlation between serum concentrations of nicotinamide phosphoribosyltransferase (NAMPT), nicotinamide nucleotide adenylyltransferase 1 (NMNAT1), and the risk of upper respiratory infections in the island reef envirsonment.
METHODS
A total of 600 cases of upper respiratory infections among naval officers and soldiers were included. Types of infection were confirmed through sputum culture combined with multiplex polymerase chain reaction. The serum concentrations of NAMPT and NMNAT1 were measured using ELISA, and infection severity was assessed using the pneumonia severity index (PSI). Statistical analysis was performed using nonparametric tests and Spearman correlation analysis.
RESULTS
The serum concentrations of NAMPT and NMNAT1 in high-risk group patients with PSI were significantly lower than those in the medium and low-risk groups (P < 0.05), and the concentrations increased in a stepwise manner with disease progression. However, within the same risk group, the differences in concentrations of NAMPT and NMNAT1 among patients infected with different pathogens were not significant (P > 0.05).
CONCLUSION
Concentrations of NAMPT and NMNAT1 are closely related to severity of upper respiratory infections, and their common regulatory mechanisms provide new directions for development of broad-spectrum anti-infection strategies.
Core Tip: This study investigated the correlation between five common respiratory pathogens in the ship environment (influenza H1N1 virus, influenza B virus, Streptococcus pneumoniae, adenovirus, and severe acute respiratory syndrome coronavirus 2) and the severity of upper respiratory tract infections in patients, as well as serum concentrations of nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide nucleotide adenylyltransferase 1 (NMNAT1). We analyzed the feasibility of using NAMPT and NMNAT1 concentrations as potential biomarkers for assessing the severity of upper respiratory tract infections, providing a basis for clinical diagnosis and treatment of personnel stationed on ships and islands.
