GPR81 nuclear transportation is critical for cancer growth: Interaction of lactate receptor signaling and cell-extracellular matrix mechanotransduction

doi:10.5306/wjco.v16.i11.112028

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Nov 24, 2025 (publication date) through Nov 21, 2025

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Clin Oncol. Nov 24, 2025; 16(11): 112028
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.112028

GPR81 nuclear transportation is critical for cancer growth: Interaction of lactate receptor signaling and cell-extracellular matrix mechanotransduction

Ilya D Klabukov, Elizabeth S Skornyakova, Denis S Baranovskii

Ilya D Klabukov, Denis S Baranovskii, Department of Regenerative Medicine, National Medical Research Radiological Center, Obninsk 249036, Russia

Ilya D Klabukov, Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University MEPhI, Obninsk 249033, Russia

Elizabeth S Skornyakova, Department of Engineering, Russian University of Transport, Moscow 127055, Moskva, Russia

Author contributions: Klabukov ID designed and performed research, and wrote the letter; Baranovskii DS analyzed data; Skornyakova ES and Baranovskii DS revised the letter.

Conflict-of-interest statement: The authors declare no conflict of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ilya D Klabukov, PhD, Director, Department of Regenerative Medicine, National Medical Research Radiological Center, 4 Koroleva Street, Obninsk 249036, Russia. ilya.klabukov@gmail.com

Received: July 16, 2025
Revised: August 12, 2025
Accepted: October 10, 2025
Published online: November 24, 2025
Processing time: 128 Days and 17 Hours

Core Tip

Core Tip: The interaction between GPR81 nuclear transport and cell-extracellular matrix mechanotransduction is a novel axis in cancer biology that could greatly affect tumor growth and progression, and could be a target for future therapeutics.