Klabukov ID, Skornyakova ES, Baranovskii DS. GPR81 nuclear transportation is critical for cancer growth: Interaction of lactate receptor signaling and cell-extracellular matrix mechanotransduction. World J Clin Oncol 2025; 16(11): 112028 [DOI: 10.5306/wjco.v16.i11.112028]
Corresponding Author of This Article
Ilya D Klabukov, PhD, Director, Department of Regenerative Medicine, National Medical Research Radiological Center, 4 Koroleva Street, Obninsk 249036, Russia. ilya.klabukov@gmail.com
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Cell Biology
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Letter to the Editor
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 24, 2025 (publication date) through Nov 21, 2025
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World Journal of Clinical Oncology
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2218-4333
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Klabukov ID, Skornyakova ES, Baranovskii DS. GPR81 nuclear transportation is critical for cancer growth: Interaction of lactate receptor signaling and cell-extracellular matrix mechanotransduction. World J Clin Oncol 2025; 16(11): 112028 [DOI: 10.5306/wjco.v16.i11.112028]
World J Clin Oncol. Nov 24, 2025; 16(11): 112028 Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.112028
GPR81 nuclear transportation is critical for cancer growth: Interaction of lactate receptor signaling and cell-extracellular matrix mechanotransduction
Ilya D Klabukov, Elizabeth S Skornyakova, Denis S Baranovskii
Ilya D Klabukov, Denis S Baranovskii, Department of Regenerative Medicine, National Medical Research Radiological Center, Obninsk 249036, Russia
Ilya D Klabukov, Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University MEPhI, Obninsk 249033, Russia
Elizabeth S Skornyakova, Department of Engineering, Russian University of Transport, Moscow 127055, Moskva, Russia
Author contributions: Klabukov ID designed and performed research, and wrote the letter; Baranovskii DS analyzed data; Skornyakova ES and Baranovskii DS revised the letter.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ilya D Klabukov, PhD, Director, Department of Regenerative Medicine, National Medical Research Radiological Center, 4 Koroleva Street, Obninsk 249036, Russia. ilya.klabukov@gmail.com
Received: July 16, 2025 Revised: August 12, 2025 Accepted: October 10, 2025 Published online: November 24, 2025 Processing time: 128 Days and 17 Hours
Abstract
The interaction between the lactate receptor GPR81 (also known as hydroxycarboxylic acid receptor 1, or HCAR1) and Splicing Factor Proline- and Glutamine-Rich protein promotes the tumor cell malignancy. GPR81 nuclear translocation plays an important role in driving cancer progression and could serve as a potential therapeutic target. Yang et al concluded in their study that lactate and its receptor, GPR81, play crucial roles in cancer progression, and are key players in linking the lactate-rich tumor microenvironment to cancer cell behavior. The ability of nuclear GPR81 to directly regulate gene expression, combined with extracellular matrix -mediated mechanical signaling, creates a potentially robust system for the coordinated adaptation and survival of cancer cells. Understanding these interactions could lead to the discovery of new therapeutic targets and improved treatment strategies for cancer.
Core Tip: The interaction between GPR81 nuclear transport and cell-extracellular matrix mechanotransduction is a novel axis in cancer biology that could greatly affect tumor growth and progression, and could be a target for future therapeutics.
