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Contents Volume 14 Issue 1 January 15, 2022

Review

Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: Progress and updates

Fan Yang, Si-Yu Sun, Sheng Wang, Jin-Tao Guo, Xiang Liu, Nan Ge, Guo-Xin Wang

World J Gastrointest Oncol 14(1):1-18. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.1

Abstract (1245) | Core Tip (1139) | Full Article (HTML) (6523) | Figures (1-1) (585) | Tables (1-2) (1190) | Full Article (PDF)-1086K (537) | Audio-686K (10) | Peer-Review Report-150K (227) | Answering Reviewers-89K (205) | Received: 04/20/2021 | Revised: 08/04/2021 | Accepted: 12/08/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (17) | Total Visits (15284) | Similar Articles (53) | Timeline of Article Publication (7) | Authors Evaluation (1) | Article Quality Tracking (2) | Cite |

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Biomarkers for response to immune checkpoint inhibitors in gastrointestinal cancers

Meng Li, Denis Kaili, Lei Shi

World J Gastrointest Oncol 14(1):19-37. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.19

Abstract (1041) | Core Tip (1045) | Full Article (HTML) (4167) | Figures (1-1) (672) | Tables (1-3) (766) | Full Article (PDF)-1238K (509) | Audio-880K (15) | Peer-Review Report-244K (194) | Answering Reviewers-132K (172) | Received: 02/22/2021 | Revised: 09/08/2021 | Accepted: 12/23/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (12) | Total Visits (13934) | Similar Articles (128) | Timeline of Article Publication (5) | Authors Evaluation (4) | Article Quality Tracking (4) | Cite |

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Proteasome regulators in pancreatic cancer

Nirosha J Murugan, Ioannis A Voutsadakis

World J Gastrointest Oncol 14(1):38-54. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.38

Abstract (1118) | Core Tip (1003) | Full Article (HTML) (4464) | Figures (1-1) (695) | Full Article (PDF)-2913K (491) | Audio-491K (19) | Peer-Review Report-130K (201) | Answering Reviewers-72K (212) | Received: 02/23/2021 | Revised: 04/14/2021 | Accepted: 12/02/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (15) | Total Visits (11763) | Similar Articles (5) | Timeline of Article Publication (3) | Authors Evaluation (1) | Article Quality Tracking (2) | Cite |

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Effects of Helicobacter pylori infection in gastrointestinal tract malignant diseases: From the oral cavity to rectum

Yang-Che Kuo, Lo-Yip Yu, Horng-Yuan Wang, Ming-Jen Chen, Ming-Shiang Wu, Chun-Jen Liu, Ying-Chun Lin, Shou-Chuan Shih, Kuang-Chun Hu

World J Gastrointest Oncol 14(1):55-74. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.55

Abstract (1277) | Core Tip (1028) | Full Article (HTML) (4300) | Figures (1-1) (662) | Tables (1-7) (723) | Full Article (PDF)-734K (430) | Audio-1619K (19) | Peer-Review Report-169K (227) | Answering Reviewers-111K (209) | Received: 03/07/2021 | Revised: 05/03/2021 | Accepted: 12/10/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (13) | Total Visits (13578) | Similar Articles (39) | Timeline of Article Publication (3) | Authors Evaluation (6) | Article Quality Tracking (2) | Cite |

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Bromodomain and extra-terminal inhibitors emerge as potential therapeutic avenues for gastrointestinal cancers

Hui-Yan Sun, Song-Tao Du, Ya-Yun Li, Guang-Tong Deng, Fu-Rong Zeng

World J Gastrointest Oncol 14(1):75-89. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.75

Abstract (1190) | Core Tip (1088) | Full Article (HTML) (5776) | Figures (1-5) (1053) | Tables (1-2) (861) | Full Article (PDF)-2119K (501) | Audio-531K (22) | Peer-Review Report-215K (191) | Answering Reviewers-104K (200) | Received: 03/17/2021 | Revised: 08/11/2021 | Accepted: 11/30/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (14) | Total Visits (14547) | Similar Articles (54) | Timeline of Article Publication (1) | Authors Evaluation (2) | Article Quality Tracking (1) | Cite |

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Gastric cancer: An epigenetic view

Si-Yuan Tang, Pei-Jun Zhou, Yu Meng, Fu-Rong Zeng, Guang-Tong Deng

World J Gastrointest Oncol 14(1):90-109. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.90

Abstract (971) | Core Tip (1037) | Full Article (HTML) (5432) | Figures (1-3) (827) | Tables (1-5) (968) | Full Article (PDF)-3332K (556) | Audio-292K (17) | Peer-Review Report-239K (208) | Answering Reviewers-133K (262) | Received: 03/21/2021 | Revised: 05/17/2021 | Accepted: 12/23/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (27) | Total Visits (14369) | Similar Articles (1291) | Timeline of Article Publication (3) | Authors Evaluation (2) | Article Quality Tracking (2) | Cite |

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Statin as a therapeutic agent in gastroenterological cancer

Norio Uemura, Hiromitsu Hayashi, Hideo Baba

World J Gastrointest Oncol 14(1):110-123. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.110

Abstract (958) | Core Tip (1028) | Full Article (HTML) (3608) | Figures (1-2) (621) | Tables (1-2) (613) | Full Article (PDF)-1126K (423) | Audio-916K (22) | Peer-Review Report-214K (167) | Answering Reviewers-506K (160) | Received: 04/29/2021 | Revised: 06/19/2021 | Accepted: 11/25/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (10) | Total Visits (10725) | Similar Articles (239) | Timeline of Article Publication (0) | Authors Evaluation (3) | Article Quality Tracking (1) | Cite |

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Development of artificial intelligence technology in diagnosis, treatment, and prognosis of colorectal cancer

Feng Liang, Shu Wang, Kai Zhang, Tong-Jun Liu, Jian-Nan Li

World J Gastrointest Oncol 14(1):124-152. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.124

Abstract (1254) | Core Tip (1048) | Full Article (HTML) (6776) | Tables (1-3) (1025) | Full Article (PDF)-784K (562) | Audio-967K (15) | Peer-Review Report-228K (248) | Answering Reviewers-30K (312) | Received: 06/15/2021 | Revised: 08/19/2021 | Accepted: 11/15/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (33) | Total Visits (15850) | Similar Articles (2327) | Timeline of Article Publication (1) | Authors Evaluation (4) | Article Quality Tracking (2) | Reader Comments (2) | Cite |

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Minireviews

Impact of the microenvironment on the pathogenesis of mucosa-associated lymphoid tissue lymphomas

Barbara Uhl, Katharina T Prochazka, Karoline Fechter, Katrin Pansy, Hildegard T Greinix, Peter Neumeister, Alexander JA Deutsch

World J Gastrointest Oncol 14(1):153-162. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.153

Abstract (1008) | Core Tip (971) | Full Article (HTML) (3414) | Figures (1-1) (573) | Full Article (PDF)-1043K (544) | Audio-210K (29) | Peer-Review Report-215K (301) | Answering Reviewers-496K (225) | Received: 02/25/2021 | Revised: 05/16/2021 | Accepted: 12/10/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (6) | Total Visits (11196) | Similar Articles (27) | Timeline of Article Publication (4) | Authors Evaluation (2) | Article Quality Tracking (1) | Cite |

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Immunotherapy in liver transplantation for hepatocellular carcinoma: Pros and cons

Yi Luo, Fei Teng, Hong Fu, Guo-Shan Ding

World J Gastrointest Oncol 14(1):163-180. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.163

Abstract (1001) | Core Tip (988) | Full Article (HTML) (5076) | Tables (1-2) (1112) | Full Article (PDF)-691K (773) | Audio-1824K (18) | Peer-Review Report-263K (207) | Answering Reviewers-210K (247) | Received: 03/22/2021 | Revised: 06/30/2021 | Accepted: 12/08/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (24) | Total Visits (13300) | Similar Articles (2479) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (1) | Cite |

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Trimodality treatment in gastric and gastroesophageal junction cancers: Current approach and future perspectives

Nikolaos Charalampakis, Sergios Tsakatikas, Dimitrios Schizas, Stylianos Kykalos, Maria Tolia, Rodanthi Fioretzaki, Georgios Papageorgiou, Ioannis Katsaros, Ahmed Adel Fouad Abdelhakeem, Matheus Sewastjanow-Silva, Jane E Rogers, Jaffer A Ajani

World J Gastrointest Oncol 14(1):181-202. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.181

Abstract (1187) | Core Tip (1019) | Full Article (HTML) (3127) | Tables (1-5) (764) | Full Article (PDF)-728K (469) | Audio-404K (7) | Peer-Review Report-662K (205) | Answering Reviewers-175K (201) | Received: 03/25/2021 | Revised: 06/28/2021 | Accepted: 12/10/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (8) | Total Visits (12097) | Similar Articles (4) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (1) | Cite |

(0) | (0) | (0) | (0) | Open

Radiofrequency ablation in the management of primary hepatic and biliary tumors

Richard Hendriquez, Tara Keihanian, Jatinder Goyal, Rtika R Abraham, Rajnish Mishra, Mohit Girotra

World J Gastrointest Oncol 14(1):203-215. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.203

Abstract (932) | Core Tip (1070) | Full Article (HTML) (4517) | Figures (1-1) (589) | Tables (1-2) (664) | Full Article (PDF)-2002K (543) | Audio-2162K (16) | Peer-Review Report-238K (307) | Answering Reviewers-168K (218) | Received: 03/28/2021 | Revised: 06/15/2021 | Accepted: 12/08/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (9) | Total Visits (11977) | Similar Articles (116) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (1) | Cite |

(0) | (0) | (0) | (0) | Open

Immune evasion mechanisms and therapeutic strategies in gastric cancer

En-Si Ma, Zheng-Xin Wang, Meng-Qi Zhu, Jing Zhao

World J Gastrointest Oncol 14(1):216-229. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.216

Abstract (1145) | Core Tip (1503) | Full Article (HTML) (5475) | Figures (1-1) (1115) | Tables (1-1) (671) | Full Article (PDF)-1058K (545) | Audio-484K (6) | Peer-Review Report-145K (197) | Answering Reviewers-38K (232) | Received: 04/22/2021 | Revised: 06/22/2021 | Accepted: 12/10/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (29) | Total Visits (14535) | Similar Articles (1297) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (2) | Cite |

(0) | (0) | (0) | (0) | Open

Early-onset colorectal cancer: Current insights and future directions

Claudia Wing-Kwan Wu, Rashid N Lui

World J Gastrointest Oncol 14(1):230-241. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.230

Abstract (1116) | Core Tip (1266) | Full Article (HTML) (8286) | Figures (1-1) (628) | Full Article (PDF)-778K (742) | Audio-582K (19) | Peer-Review Report-221K (278) | Answering Reviewers-80K (219) | Received: 06/16/2021 | Revised: 08/02/2021 | Accepted: 11/25/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (77) | Total Visits (16227) | Similar Articles (6) | Timeline of Article Publication (0) | Authors Evaluation (2) | Article Quality Tracking (1) | Cite |

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Basic Study

Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model

Fereshteh Asgharzadeh, Alex Tarnava, Asma Mostafapour, Majid Khazaei, Tyler W LeBaron

World J Gastrointest Oncol 14(1):242-252. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.242

Abstract (1643) | Core Tip (1295) | Article Highlights (1280) | Full Article (HTML) (17322) | Figures (1-4) (1112) | Full Article (PDF)-2933K (666) | Audio-1852K (47) | Peer-Review Report-217K (250) | Answering Reviewers-57K (218) | Received: 05/19/2021 | Revised: 06/30/2021 | Accepted: 12/08/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (23) | Total Visits (30336) | Similar Articles (1173) | Timeline of Article Publication (2) | Authors Evaluation (6) | Article Quality Tracking (2) | Reader Comments (2) | Cite |

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Lnc524369 promotes hepatocellular carcinoma progression and predicts poor survival by activating YWHAZ-RAF1 signaling

Wei Zheng, Guo-Liang Shen, Ke-Yang Xu, Qiao-Qiao Yin, Tian-Chen Hui, Zhe-Wen Zhou, Cheng-An Xu, Shou-Hao Wang, Wen-Hao Wu, Ling-Fei Shi, Hong-Ying Pan

World J Gastrointest Oncol 14(1):253-264. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.253

Abstract (1356) | Core Tip (893) | Article Highlights (1094) | Full Article (HTML) (3323) | Figures (1-5) (517) | Tables (1-2) (551) | Full Article (PDF)-20493K (388) | Audio-107K (18) | Peer-Review Report-153K (204) | Answering Reviewers-178K (211) | Received: 06/22/2021 | Revised: 07/28/2021 | Accepted: 09/17/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (12825) | Similar Articles (1880) | Timeline of Article Publication (0) | Authors Evaluation (3) | Article Quality Tracking (1) | Cite |

(0) | (0) | (0) | (0) | Open

Retrospective Study

Characterization of E-cadherin expression in normal mucosa, dysplasia and adenocarcinoma of gastric cardia and its influence on prognosis

Hai-Ling Wang, Xue-Ke Zhao, Fu-You Zhou, Xin Song, Liu-Yu Li, Gai-Rong Huang, Qi-De Bao, Ling-Ling Lei, Hai-Jun Yang, Li Li, Rui-Hua Xu, Ai-Li Li, Xian-Zeng Wang, Wen-Li Han, Jing-Li Ren, Li-Dong Wang

World J Gastrointest Oncol 14(1):265-277. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.265

Abstract (1026) | Core Tip (1038) | Article Highlights (1127) | Full Article (HTML) (3475) | Figures (1-3) (638) | Tables (1-4) (546) | Full Article (PDF)-3356K (380) | Audio-907K (9) | Peer-Review Report-243K (198) | Answering Reviewers-128K (189) | Supplementary Material-146K (177) | Received: 09/06/2021 | Revised: 11/18/2021 | Accepted: 12/08/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (15744) | Similar Articles (325) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (1) | Cite |

(0) | (0) | (0) | (0) | Open

Observational Study

Digestive cancer incidence and mortality among young adults worldwide in 2020: A population-based study

Jian Li

World J Gastrointest Oncol 14(1):278-294. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.278

Abstract (1008) | Core Tip (1011) | Article Highlights (1120) | Full Article (HTML) (4835) | Figures (1-8) (614) | Tables (1-2) (612) | Full Article (PDF)-3259K (648) | Audio-719K (54) | Peer-Review Report-342K (225) | Answering Reviewers-118K (196) | Supplementary Material-1154K (227) | Received: 03/18/2021 | Revised: 07/04/2021 | Accepted: 11/25/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (27) | Total Visits (14942) | Similar Articles (189) | Timeline of Article Publication (2) | Authors Evaluation (3) | Article Quality Tracking (1) | Cite |

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Prospective Study

Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival

Ramón Cantero-Cid, Karla Marina Montalbán-Hernández, Jenny Guevara, Alejandro Pascual-Iglesias, Elisa Pulido, José Carlos Casalvilla, Cristóbal Marcano, Cristina Barragán Serrano, Jaime Valentín, Gloria Cristina Bonel-Pérez, José Avendaño-Ortiz, Verónica Terrón, Roberto Lozano-Rodríguez, Alejandro Martín-Quirós, Elvira Marín, Eva Pena, Laura Guerra-Pastrián, Eduardo López-Collazo, Luis Augusto Aguirre

World J Gastrointest Oncol 14(1):295-318. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.295

Abstract (1152) | Core Tip (997) | Article Highlights (1452) | Full Article (HTML) (3699) | Figures (1-7) (594) | Tables (1-4) (610) | Full Article (PDF)-10480K (555) | Audio-1477K (11) | Peer-Review Report-238K (206) | Answering Reviewers-644K (194) | Supplementary Material-251K (287) | Received: 05/16/2021 | Revised: 07/07/2021 | Accepted: 11/30/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (16245) | Similar Articles (0) | Timeline of Article Publication (1) | Authors Evaluation (2) | Article Quality Tracking (1) | Cite |

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Randomized Controlled Trial

Effects of cognitive behavior therapy combined with Baduanjin in patients with colorectal cancer

Zheng-Gen Lin, Ren-Dong Li, Fu-Lu Ai, Song Li, Xin-An Zhang

World J Gastrointest Oncol 14(1):319-333. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.319

Abstract (1103) | Core Tip (992) | Article Highlights (1132) | Full Article (HTML) (3996) | Figures (1-3) (617) | Tables (1-7) (597) | Full Article (PDF)-1066K (419) | Audio-771K (55) | Peer-Review Report-172K (188) | Answering Reviewers-150K (182) | Received: 06/10/2021 | Revised: 07/30/2021 | Accepted: 09/10/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (13) | Total Visits (14676) | Similar Articles (1145) | Timeline of Article Publication (0) | Authors Evaluation (2) | Article Quality Tracking (1) | Cite |

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Systematic Reviews

Exosomes as potential diagnosis and treatment for liver cancer

Xiao-Cui Wei, Li-Juan Liu, Fan Zhu

World J Gastrointest Oncol 14(1):334-347. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.334

Abstract (1039) | Core Tip (1004) | Article Highlights (1037) | Full Article (HTML) (3808) | Figures (1-1) (610) | Tables (1-5) (852) | Full Article (PDF)-828K (470) | Audio-854K (11) | Peer-Review Report-156K (248) | Answering Reviewers-129K (197) | Received: 03/22/2021 | Revised: 07/03/2021 | Accepted: 09/08/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (19) | Total Visits (13056) | Similar Articles (440) | Timeline of Article Publication (9) | Authors Evaluation (1) | Article Quality Tracking (1) | Cite |

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Meta-Analysis

Increased risk of colorectal neoplasia in inflammatory bowel disease patients with post-inflammatory polyps: A systematic review and meta-analysis

De-Gao He, Xi-Jie Chen, Juan-Ni Huang, Jun-Guo Chen, Min-Yi Lv, Tian-Ze Huang, Ping Lan, Xiao-Sheng He

World J Gastrointest Oncol 14(1):348-361. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.348

Abstract (1158) | Core Tip (1547) | Article Highlights (1089) | Full Article (HTML) (3473) | Figures (1-6) (584) | Tables (1-3) (655) | Full Article (PDF)-1252K (471) | Audio-849K (10) | Peer-Review Report-216K (191) | Answering Reviewers-47K (196) | Supplementary Material-84K (307) | Received: 08/06/2021 | Revised: 09/08/2021 | Accepted: 11/25/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (8) | Total Visits (13614) | Similar Articles (1338) | Timeline of Article Publication (1) | Authors Evaluation (2) | Article Quality Tracking (1) | Cite |

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Letter to the Editor

Liquid biopsy: Precise diagnosis and therapy for cholangiocarcinoma

Si-Qin Wang, Chu-Xing Chai, Bi-Rong Wang, Feng Zhu, Dan Shang, Min Li

World J Gastrointest Oncol 14(1):362-365. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.362

Abstract (1782) | Core Tip (1493) | Full Article (HTML) (2606) | Full Article (PDF)-544K (350) | Audio-418K (42) | Peer-Review Report-219K (181) | Answering Reviewers-87K (207) | Received: 06/12/2021 | Revised: 07/19/2021 | Accepted: 11/28/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (10506) | Similar Articles (523) | Timeline of Article Publication (4) | Authors Evaluation (1) | Article Quality Tracking (2) | Cite |

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Comment on “Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis”

Xiao-Long Tang, Yan-Dong Miao, Deng-Hai Mi

World J Gastrointest Oncol 14(1):366-368. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.366

Abstract (950) | Core Tip (989) | Full Article (HTML) (2157) | Full Article (PDF)-526K (316) | Audio-658K (10) | Peer-Review Report-170K (162) | Answering Reviewers-148K (187) | Received: 06/21/2021 | Revised: 08/09/2021 | Accepted: 12/25/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (8407) | Similar Articles (2165) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (1) | Cite |

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