©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2022; 14(1): 153-162
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.153
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.153
Impact of the microenvironment on the pathogenesis of mucosa-associated lymphoid tissue lymphomas
Barbara Uhl, Katharina T Prochazka, Karoline Fechter, Katrin Pansy, Hildegard T Greinix, Peter Neumeister, Alexander JA Deutsch, Division of Hematology, Medical University of Graz, Graz 8036, Austria
Author contributions: Uhl B and Deutsch AJA drafted the work; all authors conceived the work and made substantial revisions to and critiqued the content; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Corresponding author: Alexander JA Deutsch, PhD, Research Assistant Professor, Division of Hematology, Medical University of Graz, Auenbruggerplatz 38, Graz 8036, Austria.
Received: February 25, 2021
Peer-review started: February 25, 2021
First decision: May 3, 2021
Revised: May 16, 2021
Accepted: December 9, 2021
Article in press: December 9, 2021
Published online: January 15, 2022
Processing time: 319 Days and 13.8 Hours
Peer-review started: February 25, 2021
First decision: May 3, 2021
Revised: May 16, 2021
Accepted: December 9, 2021
Article in press: December 9, 2021
Published online: January 15, 2022
Processing time: 319 Days and 13.8 Hours
Core Tip
Core Tip: This review summarizes and discusses the major findings in extranodal mucosa-associated lymphoid tissue lymphomas with a focus on the microenvironment. It describes how long-lasting chronic inflammatory processes promote the growth of malignant cells, which can be directly mediated by bacteria and/or interaction with activated immune cells. In addition, major genetic alterations are summarized, and models of how these might be acquired are discussed. Finally, novel therapies targeting the microenvironment are described.