Statin as a therapeutic agent in gastroenterological cancer

doi:10.4251/wjgo.v14.i1.110

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jan 15, 2022; 14(1): 110-123
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.110

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Figure 1 The mevalonate pathway and the SREBPs-mediated feedback response. SREBP: Sterol regulatory element-binding protein; LDL: Low density lipoprotein; LDLR: Low density lipoprotein receptor; HMGCR: 3-hydroxy-3-methylglutaryl coenzyme A reductase.

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Figure 2 Activation of the mevalonate pathway drives oncogenic signaling pathways. MVA: Mevalonate; HH: Hedgehog; YAP: Yes-associated protein; TAZ: Transcriptional co-activator with PDZ-binding motif.

Citation: Uemura N, Hayashi H, Baba H. Statin as a therapeutic agent in gastroenterological cancer. World J Gastrointest Oncol 2022; 14(1): 110-123
URL: https://www.wjgnet.com/1948-5204/full/v14/i1/110.htm
DOI: https://dx.doi.org/10.4251/wjgo.v14.i1.110