Post-translational modifications in osteogenic differentiation of oral-derived stem cells: Mechanisms and clinical implications

doi:10.4252/wjsc.v17.i9.109662

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 9

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (1468)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-3) series.

Item

Count

PDF

HTML

218

Figures (1-1)

Tables (1-3)

Sum=409

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

497

Download

226

Sum=723

Publishing Process of This Article

Item

Count

Browse

Download

209

Sum=265

Sep 26, 2025 (publication date) through Mar 18, 2026

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Stem Cells

ISSN

1948-0210

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

World J Stem Cells. Sep 26, 2025; 17(9): 109662
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.109662

Post-translational modifications in osteogenic differentiation of oral-derived stem cells: Mechanisms and clinical implications

Zhuo-Jin Shi, Wei Liu

Zhuo-Jin Shi, School/Hospital of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China

Wei Liu, Department of Oral Medicine, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China

Author contributions: Shi ZJ conducted literature review and drafted the manuscript; Liu W conceptualized the study, provided critical revisions, and supervised the overall work.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Wei Liu, DDS, Associate Chief Physician, Department of Oral Medicine, The Second Affiliated Hospital Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. liuwei1982@zju.edu.cn

Received: May 18, 2025
Revised: June 22, 2025
Accepted: August 13, 2025
Published online: September 26, 2025
Processing time: 129 Days and 21.3 Hours

Core Tip

Core Tip: This review clarifies how post-translational modifications (PTMs), including phosphorylation, acetylation, methylation, and lactylation, dynamically modulate the osteogenic differentiation of oral-derived stem cells (ODSCs) under inflammatory or hypoxic conditions. We highlight PTMs as essential molecular switches integrating extracellular signals with transcriptional and epigenetic mechanisms to facilitate bone regeneration. Emerging therapeutic strategies - including histone deacetylase inhibitors, extracellular vesicle-based delivery, and metabolic-epigenetic crosstalk modulation - are proposed to improve ODSCs efficacy in osteoporosis and periodontitis. This review clarifies the PTMs “regulatory code” in ODSCs, connecting mechanistic insights to clinical translation while addressing unresolved challenges in precision regenerative medicine.