Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2025; 17(9): 106381
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.106381
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.106381
Expression of cancer stem cell markers and their prognostic significance in stage IIIA non-small cell lung cancer
Tao Lin, Wen-Zhen Xu, Cai-Jin Jin, Department of Cardio-Thoracic Surgery, Sanmen People’s Hospital, Sanmen 317100, Zhejiang Province, China
Si-Cong Jiang, Department of Thoracic and Endocrine Surgery, University Hospitals and University of Geneva, Geneva 450000, Switzerland
Xian-Ming He, Department of Oncology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
You-Dan Guo, Department of Respiratory Disease, Jiangxi Provincial People’s Hospital, Nanchang 330006, Jiangxi Province, China
Author contributions: Lin T and Jiang SC prepared the figures; Lin T, Jiang SC, Jin CJ, and Guo YD wrote and improved the main manuscript; He XM and Xu WZ contributed to revision of the main manuscript text and prepared the table; Jin CJ and Guo YD contributed to supervision and replied to review comments; All authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the First Affiliated Hospital of Nanchang Medical College (approval number: FA240011).
Informed consent statement: Informed consent to participate was obtained from all participants in the study.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: You-Dan Guo, Department of Respiratory Disease, Jiangxi Provincial People’s Hospital, No. 92 Aiguo Road, Nanchang 330006, Jiangxi Province, China.
Received: March 21, 2025
Revised: May 16, 2025
Accepted: August 4, 2025
Published online: September 26, 2025
Processing time: 187 Days and 12.8 Hours
Revised: May 16, 2025
Accepted: August 4, 2025
Published online: September 26, 2025
Processing time: 187 Days and 12.8 Hours
Core Tip
Core Tip: In patients with stage IIIA non-small cell lung cancer, older age and the presence of micropapillary components were significantly associated with worse overall survival, indicating their potential role in risk stratification. Furthermore, high expression of octamer-binding transcription factor 4 and elevated mRNA expression-based stemness index, both markers of tumor stemness, were closely linked to poor prognosis. These factors may serve not only as important prognostic indicators but also as potential therapeutic targets, contributing to more personalized and effective treatment strategies in clinical practice.