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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Oct 26, 2025; 17(10): 111241
Published online Oct 26, 2025. doi: 10.4252/wjsc.v17.i10.111241
Published online Oct 26, 2025. doi: 10.4252/wjsc.v17.i10.111241
Role of mesenchymal stem cell-derived exosomal non-coding RNAs in bone and bone-related disorders
Deekshaa Chidambaram, Velan Subashini, Muthuvairaprasath Nanthanalaxmi, Nagarajan Selvamurugan, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nādu, India
Author contributions: Chidambaram D, Subashini V, and Nanthanalaxmi M wrote the manuscript; Selvamurugan N acquired funding for this project and edited and evaluated the manuscript. All authors approved the final version of the manuscript.
Supported by Anusandhan National Research Foundation, No. CRG/2023/000212.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nagarajan Selvamurugan, PhD, Professor, Department of Biote chnology, School of Bioengineering, SRM Institute of Science and Technology, SRM Nagar, Potheri, Kattankulathur 603203, Tamil Nādu, India. selvamun@srmist.edu.in
Received: June 26, 2025
Revised: August 13, 2025
Accepted: September 22, 2025
Published online: October 26, 2025
Processing time: 121 Days and 11 Hours
Revised: August 13, 2025
Accepted: September 22, 2025
Published online: October 26, 2025
Processing time: 121 Days and 11 Hours
Core Tip
Core Tip: Mesenchymal stem cell-derived exosomal non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, play vital roles in regulating bone development, remodeling, and the pathogenesis of bone-related disorders. This review provides insights into their emerging roles in bone biology and disease, highlighting their therapeutic potential and underlying molecular mechanisms.
