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World J Stem Cells. Oct 26, 2025; 17(10): 111241
Published online Oct 26, 2025. doi: 10.4252/wjsc.v17.i10.111241
Role of mesenchymal stem cell-derived exosomal non-coding RNAs in bone and bone-related disorders
Deekshaa Chidambaram, Velan Subashini, Muthuvairaprasath Nanthanalaxmi, Nagarajan Selvamurugan
Deekshaa Chidambaram, Velan Subashini, Muthuvairaprasath Nanthanalaxmi, Nagarajan Selvamurugan, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nādu, India
Author contributions: Chidambaram D, Subashini V, and Nanthanalaxmi M wrote the manuscript; Selvamurugan N acquired funding for this project and edited and evaluated the manuscript. All authors approved the final version of the manuscript.
Supported by Anusandhan National Research Foundation, No. CRG/2023/000212.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nagarajan Selvamurugan, PhD, Professor, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, SRM Nagar, Potheri, Kattankulathur 603203, Tamil Nādu, India. selvamun@srmist.edu.in
Received: June 26, 2025
Revised: August 13, 2025
Accepted: September 22, 2025
Published online: October 26, 2025
Processing time: 121 Days and 11 Hours
Core Tip

Core Tip: Mesenchymal stem cell-derived exosomal non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, play vital roles in regulating bone development, remodeling, and the pathogenesis of bone-related disorders. This review provides insights into their emerging roles in bone biology and disease, highlighting their therapeutic potential and underlying molecular mechanisms.