Adenomyoepithelioma of the breast with malignant transformation and repeated local recurrence: A case report

Table 1 Malignant adenomyoepithelioma cases reported over the last 5 years

No	Ref.	Age	Malignant components	Surgery	Local recurrence	Distant recurrence	Outcome	MMG	US	MRI	Biopsy
1	Jones et al[5]	78	Epithelial and myoepithelial	Lumpectomy→mastectomy+SNB	No	No	1-yr survival	NA	NA	NA	CNB(suspicious for AME)
2	Yuan et al[6]	51	NA	Lumpectomy→lumpectomy→mastectomy+SNB	Unknowno	Unknown	Unknown	Mass	Cyst-solid space-occupying lesions	Enhanced mass with suspected invasion of surrounding tissue	CNB (suspicious for AME)
3	Yuan et al[6]	58	NA	Lumpectomy→mastectomy	Yes	Yes (bone, carcinomatous pleurisy)	Died after 22 months	NA	NA	NA	CNB (suspicious for AME)
4	Hempenstall et al[7]	45	Epithelial and myoepithelial	Lumpectomy	No	No	Survival (period unknown)	Mass	Heterogeneously hypoechoic mass	NA	CNB (diagnosis of phyllodes tumor)
5	Watanabe et al[8]	41	Epithelial and myoepithelial	Lumpectomy→mastectomy	Yes	Yes (lung)	Unknown	Mass	NA	NA	CNB (diagnosis of papilloma)
6	Kakkar et al[9]	36	Myoepithelial predominant	Lumpectomy+SNB	No	No	1-yr survival	Mass	NA	Lobulated mass with infiltrative margins	CNB (diagnosis of invasive carcinoma)
7	Febres-Aldana et al[10]	47	Epithelial and myoepithelial	Lumpectomy	No	No	1-yr survival	Mass	NA	NA	CNB (diagnosis of malignant AME)
8	Lari et al[11]	39	Epithelial and myoepithelial	Lumpectomy→mastectomy+ALND	No	No	Unknown	Ill-defined irregular mass	Low echoic mass	NA	CNB (suspicious for AME)
9	Moro et al[12]	64	Epithelial and myoepithelial	Lumpectomy→mastectomy+ALND	Yes	Yes (lung)	Died 17 months later	NA	Hypoechoic mass with cystic lesion	Multiple masses with invasion of the skin and pectoralis muscle	CNB (diagnosis of AME)
10	Zhang et al[13]	64	Malignant degeneration of the myoepithelium	Lumpectomy+SNB	No	No	1-yr survival	Mass	Hypoechoic mass	NA	Excisional biopsy(diagnosis of ductal carcinoma)
11	Parikh et al[14]	61	Epithelial and myoepithelial	Lumpectomy	No	No	Unknown	FAD	Heterogeneously hypoechoic	NA	CNB(suspicious for AME)
12	Our case	53	Myoepithelial predominant	Lumpectomy→lumpectomy→mastectomy	Yes	No	2-yr survival	Mass	Mass with cystic change	Multiple masses with cystic change with invasion of the pectoralis muscle	CNB(diagnosis of AME)

NA: Not applicable; SNB: Sentinel node biopsy; ALND: Axillary lymph node dissection; MMG: Mammography; FAD: Focal asymmetric density; CNB: Core needle biopsy; AME: Adenomyoepithelioma.