Oda G, Nakagawa T, Mori M, Fujioka T, Onishi I. Adenomyoepithelioma of the breast with malignant transformation and repeated local recurrence: A case report. World J Clin Cases 2021; 9(29): 8864-8870 [PMID: 34734068 DOI: 10.12998/wjcc.v9.i29.8864]
Corresponding Author of This Article
Tsuyoshi Nakagawa, MD, PhD, Doctor, Department of Breast Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunnkyo-ku, Tokyo 113-8519, Japan. dgsh197877@hotmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Goshi Oda, Tsuyoshi Nakagawa, Department of Breast Surgery, Tokyo Medical and Dental University, Tokyo 113-8519, Japan
Mio Mori, Tomoyuki Fujioka, Department of Radiology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan
Iichiro Onishi, Department of Pathology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan
Author contributions: Goshi O performed surgery, and wrote the manuscript; Tsuyoshi N performed surgery and collected data; Mio M and Tomoyuki F were responsible for diagnostic imaging and ultrasound-guided needle biopsy; Iichiro O was in charge of the pathology; all authors read and approved the final version.
Informed consent statement: Written and signed informed consent for publication of this case was obtained from the patient.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tsuyoshi Nakagawa, MD, PhD, Doctor, Department of Breast Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunnkyo-ku, Tokyo 113-8519, Japan. dgsh197877@hotmail.com
Received: May 31, 2021 Peer-review started: May 31, 2021 First decision: June 24, 2021 Revised: July 5, 2021 Accepted: August 23, 2021 Article in press: August 23, 2021 Published online: October 16, 2021 Processing time: 137 Days and 3.3 Hours
Abstract
BACKGROUND
Adenomyoepithelioma (AME) of the breast is a rare type of benign breast tumor. Many AMEs show benign behavior, but reports of the malignant type are rare. We present the case of a patient with AME with repeated local recurrences and further malignant transformation.
CASE SUMMARY
A 53-year-old woman visited our hospital with a 16-mm palpable mass in the right breast. A core needle biopsy was performed. The pathological diagnosis was AME. Lumpectomy with a safety margin was performed without axillary lymph node dissection (ALND). Two years later, local recurrence developed, and the patient again underwent lumpectomy with a safety margin. The pathology showed malignant AME, and the margin was negative. Eight months later, local recurrence developed again in the same location, and a total mastectomy was performed without ALND. The pathological diagnosis was malignant AME. The patient was disease-free for three years posttreatment.
CONCLUSION
The treatment of AME requires caution, as it may exhibit repeated recurrences after local excision as well as malignant transformation.
Core Tip: Adenomyoepithelioma (AME) of the breast is a very rare type of benign tumor of the breast. Many AMEs demonstrate benign behavior and are often cured with excision with negative margins, but some AMEs exhibit malignant transformation of the myoepithelium, glandular epithelium, or both. We report the case of a patient with AME with repeated local recurrences and malignant transformation.
