Thyroid nodules as predictors of adenomatous colonic polyps: A systematic review and meta-analysis

Table 1 Relationship between thyroid nodules and colonic polyps

Ref.	Country	Methodology	Polyps and nodules in cases	Polyps and nodules in controls	Results
Duran et al[19], 2012	Türkiye	Case-control	44/66	61/146	More nodules in patients with polyps, P = 0.001
Mousa et al[20], 2019	United Kingdom	Case-control	55/105	24/68	More nodules in patients with polyps, P = 0.017
Ozturk et al[21], 2022	Türkiye	Retrospective	15/20	36/103	More nodules in patients with polyps, P < 0.03
Park et al[22], 2015	Korea	Prospective	63/266	37/277	No significant difference
Yu et al[23], 2021	China	Case-control	542/1379	1035/3135	More nodules in patients with polyps, P < 0.001

Table 2 Risk factors for thyroid nodules among the study group

Ref.	Age	Females%	Obesity/BMI	Waist	Smoking
Duran et al[19], 2012	53.3 ± 11.4 vs 51.8 ± 11.4	Matched	Not assessed	Not assessed	Not assessed
Mousa et al[20], 2019	54.48 ± 10.01 vs 51.87 ± 10. 86	47.3% vs 52.7%	28.88 ± 7.66 vs 27.99 ± 4. 06	50.6% vs 49.4% high waist	Not assessed
Ozturk et al[21], 2022	61.95 ± 9.01 vs 57.13 ± 14.49	35% vs 69 67%	Not assessed	Not assessed	Not assessed
Park et al[22], 2015	52.08 ± 11.48 vs 47.02 ± 9.26	36.5% vs 55.6%	37.2% vs 27.1%	83.56 ± 9.16 vs 80.20 ± 9.07	16.5% vs 10.5%
Yu et al[23], 2021	50 vs 45	25.1% vs 43.6%	24.5 vs 23.3%	3.24 ± 9.58	39.3% vs 23.5%

BMI: Body mass index.

Table 3 Thyroid stimulating hormone levels among patients with and without thyroid polyps

Ref.	TSH among patients with nodules	TSH among patients without nodules
Duran et al[19], 2012	1.17 ± 0.95	1.54 ± 1.3
Mousa et al[20], 2019	1.40 ± 0.84	1.72 ± 0.97
Ozturk et al[21], 2022	2.76 ± 2.91	3.24 ± 9.58
Park et al[22], 2015	2.73 ± 7.25	1.69 ± 1.06
Yu et al[23], 2021	1.54	1.64

TSH: Thyroid-stimulating hormone.

Table 4 Newcastle Ottawa scale risk of bias of the included studies

Ref.	Country	Selection bias	Comparability	Outcome	Total score
Duran et al[19], 2012	Türkiye	4	2	2	8
Mousa et al[20], 2019	United Kingdom	4	2	2	8
Ozturk et al[21], 2022	Türkiye	4	2	2	8
Park et al[22], 2015	Korea	4	2	2	8
Yu et al[23], 2021	China	4	2	3	9