Immunoglobulin replacement therapy and infection risk in chronic lymphocytic leukemia: A systematic review and meta-analysis

Figure 1 Flowchart of the study selection process.

Figure 2 Forest plot. A: Rate-based analysis presented as rate ratio; B: Dichotomous analysis presented as risk ratio. IgRT: Immunoglobulin replacement therapy; IVIg: Intravenous immunoglobulin; SCIg: Subcutaneous immunoglobulin; RR: Risk ratio; CI: Confidence interval.

Figure 3 Risk of bias. A: Each observational study according to risk of bias in nonrandomized studies of interventions version I tool; B: Each domain for the observational studies; C: Each randomized controlled trial according to Cochrane risk of bias 2 tool; D: Each domain for randomized controlled trials.

Figure 4 Funnel plot. A: Assessing publication bias for the dichotomous meta-analysis of infection risk (risk ratios); B: Assessing publication bias for the rate-based meta-analysis of infections per patient-year (rate ratios).