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World J Clin Cases. Oct 26, 2021; 9(30): 8967-8973
Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.8967
Regulation of bone metabolism mediated by β-adrenergic receptor and its clinical application
Xue-Ping Zhong, Wen-Fang Xia
Xue-Ping Zhong, Wen-Fang Xia, Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Author contributions: Zhong XP performed the majority of the writing, prepared the figure; Xia WF designed the research study and coordinated the writing of the paper; All authors have read and approve the final manuscript.
Supported by National Natural Sciences Foundation of China, No. 81200649; Natural Sciences Foundation of Hubei Province of China, No. 2016CFB425; and Fundamental Research Funds for the Central University, No. 2016YXMS236.
Conflict-of-interest statement: The authors declare that they have no conflicting interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Fang Xia, MD, Associate Professor, Doctor, Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. xiawenfang@hust.edu.cn
Received: January 12, 2021
Peer-review started: January 12, 2021
First decision: July 5, 2021
Revised: July 18, 2021
Accepted: September 1, 2021
Article in press: September 1, 2021
Published online: October 26, 2021
Processing time: 281 Days and 18.1 Hours
Core Tip

Core Tip: β-Adrenergic receptors (β-ARs) are widely used clinically in senile cardiovascular diseases. As β-AR blockers (BBs) are involved in the regulation of bone metabolism, it is worth exploring they have beneficial effects on bone metabolism in the treatment of cardiovascular diseases. This article reviews the mechanisms of BBs in bone metabolism and its clinical applications.