Regulation of bone metabolism mediated by β-adrenergic receptor and its clinical application

doi:10.12998/wjcc.v9.i30.8967

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World Journal of Clinical Cases

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World J Clin Cases. Oct 26, 2021; 9(30): 8967-8973
Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.8967

Regulation of bone metabolism mediated by β-adrenergic receptor and its clinical application

Xue-Ping Zhong, Wen-Fang Xia

Xue-Ping Zhong, Wen-Fang Xia, Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China

Author contributions: Zhong XP performed the majority of the writing, prepared the figure; Xia WF designed the research study and coordinated the writing of the paper; All authors have read and approve the final manuscript.

Supported by National Natural Sciences Foundation of China, No. 81200649; Natural Sciences Foundation of Hubei Province of China, No. 2016CFB425; and Fundamental Research Funds for the Central University, No. 2016YXMS236.

Conflict-of-interest statement: The authors declare that they have no conflicting interest.

Corresponding author: Wen-Fang Xia, MD, Associate Professor, Doctor, Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. xiawenfang@hust.edu.cn

Received: January 12, 2021
Peer-review started: January 12, 2021
First decision: July 5, 2021
Revised: July 18, 2021
Accepted: September 1, 2021
Article in press: September 1, 2021
Published online: October 26, 2021
Processing time: 281 Days and 18.1 Hours

Abstract

Recent studies have confirmed that β-adrenergic receptors (β-ARs) are expressed on the surface of osteoblasts and osteoclasts, and that the sympathetic nervous system can regulate bone metabolism by activating them. β-AR blockers (BBs) are commonly used in the treatment of cardiovascular diseases in the elderly. It is important to investigate whether BBs have a beneficial effect on bone metabolism in the treatment of cardiovascular diseases, so as to expand their clinical application. This article reviews the effects of BB on bone metabolism and the progress of clinical research.

Keywords: β-Adrenergic receptors; Bone metabolism; β-Adrenergic receptor blocker; β-Adrenergic; Skeletal system

Core Tip: β-Adrenergic receptors (β-ARs) are widely used clinically in senile cardiovascular diseases. As β-AR blockers (BBs) are involved in the regulation of bone metabolism, it is worth exploring they have beneficial effects on bone metabolism in the treatment of cardiovascular diseases. This article reviews the mechanisms of BBs in bone metabolism and its clinical applications.