Kim YJ, Lee JM, Lee JH. Predictive factors for early clinical response in community-onset Escherichia coli urinary tract infection and effects of initial antibiotic treatment on early clinical response. World J Clin Cases 2020; 8(19): 4342-4348 [PMID: 33083393 DOI: 10.12998/wjcc.v8.i19.4342]
Corresponding Author of This Article
Jae-Hoon Lee, MD, PhD, Doctor, Professor, Department of Internal Medicine and Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, 460, Iksandaero, Iksan 54538, South Korea. john7026@wku.ac.kr
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 6, 2020 (publication date) through Nov 3, 2025
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Publication Name
World Journal of Clinical Cases
ISSN
2307-8960
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Kim YJ, Lee JM, Lee JH. Predictive factors for early clinical response in community-onset Escherichia coli urinary tract infection and effects of initial antibiotic treatment on early clinical response. World J Clin Cases 2020; 8(19): 4342-4348 [PMID: 33083393 DOI: 10.12998/wjcc.v8.i19.4342]
World J Clin Cases. Oct 6, 2020; 8(19): 4342-4348 Published online Oct 6, 2020. doi: 10.12998/wjcc.v8.i19.4342
Predictive factors for early clinical response in community-onset Escherichia coli urinary tract infection and effects of initial antibiotic treatment on early clinical response
Young Jun Kim, Jeong-Mi Lee, Jae-Hoon Lee
Young Jun Kim, Department of Internal Medicine, Wonkwang University College of Medicine, Iksan 54538, South Korea
Jeong-Mi Lee, Department of Public Health, Wonkwang University College of Medicine, Iksan 54538, South Korea
Jae-Hoon Lee, Department of Internal Medicine and Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan 54538, South Korea
Author contributions: Kim YJ designed the study and collected the data and drafted the article; Lee JM analyzed the data; Lee JH supervised the study and revised the manuscript; all authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the institutional review board of WKUH 2020-03-023.
Informed consent statement: This study only was a review of non-identified existing recordings. So, the informed consent was exempt from IRB.
Conflict-of-interest statement: All authors declare no conflict of interest.
Data sharing statement: No additional data.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jae-Hoon Lee, MD, PhD, Doctor, Professor, Department of Internal Medicine and Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, 460, Iksandaero, Iksan 54538, South Korea. john7026@wku.ac.kr
Received: May 8, 2020 Peer-review started: May 8, 2020 First decision: May 21, 2020 Revised: June 1, 2020 Accepted: September 2, 2020 Article in press: September 2, 2020 Published online: October 6, 2020 Processing time: 142 Days and 15 Hours
Core Tip
Core Tip: It is necessary to evaluate the clinical response of patients with urinary tract infections (UTIs) after 72 h of antibiotic therapy as poor clinical response has been related to clinical failure. We performed a single center retrospective study including 511 hospitalized patients (aged ≥ 18 years) who were diagnosed with community-onset Escherichia coli (E. coli) UTI. Among them, 66.1% of the patients had an early clinical response. Patients with an early clinical response had a shorter length of stay (4.3 d) and an earlier defervescence (64 h) than those without an early clinical response. An appropriate initial antibiotic therapy, extended-spectrum β-lactamase-producing E. coli, and a stay in a healthcare facility before admission were factors associated with an early clinical response. However, the initial broad-spectrum antibiotic therapy or initial severe presentations did not impact early clinical response.
