Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Clin Cases. Mar 26, 2026; 14(9): 118634
Published online Mar 26, 2026. doi: 10.12998/wjcc.v14.i9.118634
Published online Mar 26, 2026. doi: 10.12998/wjcc.v14.i9.118634
Carbamazepine-induced hyponatremia following meningioma surgery: A case report
Emir Begagić, Hakija Bečulić, Anes Mašović, Fahrudin Alić, Department of Neurosurgery, Cantonal Hospital Zenica, Zenica 72000, Bosnia and Herzegovina
Emir Begagić, Hakija Bečulić, Department of General Medicine, University of Zenica, Zenica 72000, Bosnia and Herzegovina
Mirza Huremović, Department of Emergency Medicine, Cantonal Hospital Zenica, Zenica 72000, Bosnia and Herzegovina
Semir Vranić, College of Medicine, Qatar University, Doha 2713, Ad Dawah, Qatar
Author contributions: Begagić E designed the research study; Begagić E, Bečulić H, Mašović A, and Alić F performed the research; Bečulić H and Vranić S supervised the research; Begagić E, Bečulić H, Mašović A, Alić F, Huremović M, and Vranić S wrote the manuscript; and all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Emir Begagić, MD, Principal Investigator, Department of Neurosurgery, Cantonal Hospital Zenica, Crkvice 67, Zenica 72000, Bosnia and Herzegovina.
Received: January 12, 2026
Revised: February 12, 2026
Accepted: February 27, 2026
Published online: March 26, 2026
Processing time: 76 Days and 6.4 Hours
Revised: February 12, 2026
Accepted: February 27, 2026
Published online: March 26, 2026
Processing time: 76 Days and 6.4 Hours
Core Tip
Core Tip: A 62-year-old woman developed progressive symptomatic hypotonic euvolemic hyponatremia after frontobasal meningioma resection shortly after starting carbamazepine (CBZ) for postoperative seizure prophylaxis. Despite isotonic saline, sodium fell to 119 mmol/L with somnolence; investigations supported a syndrome of inappropriate antidiuretic hormone secretion like pattern. Discontinuation of CBZ with substitution to levetiracetam, alongside hypertonic saline, led to clinical recovery and sustained normalization of serum sodium.