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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2026; 14(5): 117846
Published online Feb 16, 2026. doi: 10.12998/wjcc.v14.i5.117846
Published online Feb 16, 2026. doi: 10.12998/wjcc.v14.i5.117846
Atherogenic index of plasma in stroke: A comprehensive review of its diagnostic, prognostic, and pathophysiological significance
Hemanth Dhananjaya, Himanshu S Jog, Department of Medicine, MS Ramaiah Medical College, Bengaluru 560054, Karnataka, India
Shashank Gupta, Department of Medicine, Mayo Clinic, Rochester, MN 55905, United States
Arankesh Mahadevan, Department of Neurology, University of Utah Health, Salt Lake City, UT 84132, United States
Shaylika Chauhan, Department of Internal Medicine, Geisinger Health System, Wilkes-Barre, PA 18711, United States
Rupak Desai, Independent Researcher, Outcomes Research, Atlanta, GA 30033, United States
Author contributions: Dhananjaya H, Jog H S, Gupta S, and Mahadevan A contributed to writing-original draft; Dhananjaya H and Jog H S contributed to data curation; Gupta S, Mahadevan A, and Chauhan S contributed to writing - review and editing; Chauhan S and Desai R contributed to conceptualization and visualization; Chauhan S contributed to supervision; Desai R contributed to methodology, formal analysis, resources. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shaylika Chauhan, MD, FACP, FRCP, Department of Internal Medicine, Geisinger Health System, 1000 E Mountain Blvd, Wilkes-Barre, PA 18711, United States.
Received: December 23, 2025
Revised: January 12, 2026
Accepted: February 4, 2026
Published online: February 16, 2026
Processing time: 50 Days and 3.6 Hours
Revised: January 12, 2026
Accepted: February 4, 2026
Published online: February 16, 2026
Processing time: 50 Days and 3.6 Hours
Core Tip
Core Tip: The atherogenic index of plasma (AIP), calculated as the logarithmic ratio of triglycerides to high-density lipoprotein cholesterol, is an emerging cardiometabolic biomarker that integrates dyslipidemia and insulin resistance. This review highlights consistent evidence linking elevated AIP with increased ischemic stroke risk, greater stroke severity, early neurological deterioration, and poorer outcomes, particularly in individuals with diabetes and metabolic syndrome. By reflecting endothelial dysfunction, vascular inflammation, and atherosclerotic burden, AIP offers a low-cost, readily available tool with potential to enhance stroke risk stratification and preventive cardiometabolic care.