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Olanzapine-based vs neurokinin-1 receptor antagonist antiemetic regimens in highly emetogenic chemotherapy: Systematic review and meta-analysis of efficacy and safety
Advaitha Mv, Nikhilesh Anand, Biacin Babu, Ayoola Awosika, Uttam Udayan, Jacqueline Mendoza, Alissa Lopez, Brahmaiahchari Rangachari, Sabyasachi Maity, Bharathi S Gadad
Advaitha Mv, Department of Pharmacology, Nitte (Deemed to be University), KS Hegde Medical Academy, Mangalore 575018, Karnātaka, India
Nikhilesh Anand, Uttam Udayan, Jacqueline Mendoza, Alissa Lopez, Bharathi S Gadad, Department of Medical Education, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX 78542, United States
Biacin Babu, Department of Pharmacology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi 110029, Delhi, India
Ayoola Awosika, Department of Family and Community Medicine, University of Illinois College of Medicine Peoria, Bloomington, IL 61601, United States
Brahmaiahchari Rangachari, Department of Pathology, Kentucky College of Osteopathic Medicine, Pikeville, KY 41501, United States
Sabyasachi Maity, Department of Cellular and Integrative Physiology, Long School of Medicine, UT Health San Antonio, San Antonio, TX 78015, United States
Author contributions: Mv A, Anand N, Babu B, Awosika A, and Udayan U contributed to conceptualization and overall coordination; Mv A, Anand N, Babu B, Awosika A, Udayan U, Mendoza J, Rangachari B, Maity S, and Gadad BS contributed to literature search, evidence acquisition and data extraction, interpretation and synthesis of evidence, and writing - original draft preparation; Mv A, Anand N, Babu B, Awosika A, Mendoza J, Lopez A, Gadad BS contributed to writing - review and editing; Mv A and Awosika A contributed to supervision and senior oversight. All authors agreed and are accountable for all aspects of the work in ensuring accuracy/integrity of all sections of the manuscript, and everyone have given final approval of the manuscript version to be published.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Ayoola Awosika, MD, Department of Family and Community Medicine, University of Illinois College of Medicine Peoria, 1 Illini Drive, Bloomington, IL 61601, United States.
ayoolaawosika@yahoo.com
Received: January 20, 2026
Revised: February 3, 2026
Accepted: March 6, 2026
Published online: April 26, 2026
Processing time: 86 Days and 2.8 Hours
