D’Souza OK. Comparative evaluation of anesthetic efficacy of articaine vs lignocaine during root canal therapy in hypomineralized second primary molars. World J Clin Cases 2026; 14(10): 118053 [DOI: 10.12998/wjcc.v14.i10.118053]
Corresponding Author of This Article
Olando Kevin D'Souza, Consultant, Department of Pedodontics and Preventive Dentistry, Goa Dental College and Hospital, Near Goa Medical College, Bambolim 403202, Goa, India. olandokevindsouza@gmail.com
Research Domain of This Article
Pediatrics
Article-Type of This Article
Randomized Controlled Trial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Apr 6, 2026 (publication date) through Apr 5, 2026
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Journal Information of This Article
Publication Name
World Journal of Clinical Cases
ISSN
2307-8960
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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D’Souza OK. Comparative evaluation of anesthetic efficacy of articaine vs lignocaine during root canal therapy in hypomineralized second primary molars. World J Clin Cases 2026; 14(10): 118053 [DOI: 10.12998/wjcc.v14.i10.118053]
Comparative evaluation of anesthetic efficacy of articaine vs lignocaine during root canal therapy in hypomineralized second primary molars
Olando Kevin D’Souza
Olando Kevin D’Souza, Department of Pedodontics and Preventive Dentistry, Goa Dental College and Hospital, Bambolim 403202, Goa, India
Author contributions: D’Souza OK conceptualized and designed the study, collected data, and carried out the initial analyses and manuscript writing.
Institutional review board statement: Ethical approval was obtained from the Institutional Ethics Committee of Goa Dental College and Hospital (No. GDCH/IRB/V-2025/RPN29-29).
Clinical trial registration statement: The manuscript has been registered at https://www.ctri.nic.in/, No. CTRI/2025/08/092581.
Informed consent statement: All participants provided informed consent.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: Deidentified individual participant data (including data dictionaries), along with the study protocol, statistical analysis plan, and informed consent form, will be made available upon publication. Data access will be granted to researchers who submit a methodologically sound proposal aligned with the objectives of the approved study. Proposals should be submitted to olandokevindsouza@gmail.com.
Corresponding author: Olando Kevin D'Souza, Consultant, Department of Pedodontics and Preventive Dentistry, Goa Dental College and Hospital, Near Goa Medical College, Bambolim 403202, Goa, India. olandokevindsouza@gmail.com
Received: December 23, 2025 Revised: February 10, 2026 Accepted: March 6, 2026 Published online: April 6, 2026 Processing time: 100 Days and 23.3 Hours
Core Tip
Core Tip: Achieving effective pulpal anesthesia in hypomineralized second primary molars is often challenging with conventional local anesthetics. This split-mouth clinical study demonstrates that 4% articaine provides superior intraoperative anesthetic efficacy compared with 2% lignocaine during root canal treatment of hypomineralized second primary molars, particularly during access cavity preparation and canal instrumentation. While both agents showed comparable discomfort during injection, articaine achieved more profound and consistent pulpal anesthesia. The findings underscore the clinical importance of selecting anesthetic agents with enhanced tissue penetration for hypomineralized teeth and provide evidence-based guidance for improving pain control and treatment outcomes in pediatric endodontic practice.
