©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2025; 13(33): 112305
Published online Nov 26, 2025. doi: 10.12998/wjcc.v13.i33.112305
Published online Nov 26, 2025. doi: 10.12998/wjcc.v13.i33.112305
Recurrent hemoptysis after laryngectomy-acquired hemophilia induced by laryngeal cancer surgery and chemoradiotherapy: A case report
Peng-Wei Zhao, Yan-Sheng Hu, Zheng Jiang, Mailudan Ainiwaer, Jun Liu, Fei Chen, Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610048, Sichuan Province, China
Peng-Wei Zhao, Yan-Sheng Hu, Zheng Jiang, Mailudan Ainiwaer, Jun Liu, Fei Chen, Head and Neck Surgical Center, West China Hospital, Sichuan University, Chengdu 610048, Sichuan Province, China
Co-first authors: Peng-Wei Zhao and Yan-Sheng Hu.
Author contributions: Zhao PW and Hu YS contributed equally to this work, were responsible for conceptualization, data collection, and drafting the manuscript; Jiang Z and Ainiwaer M involved in patient management, data interpretation, and critical revision of the manuscript; Liu J contributed to the literature review and data analysis; Chen F supervised the study, provided critical feedback, and finalized the manuscript; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest regarding the publication of this paper.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Fei Chen, MD, PhD, Associate Professor, Department of Otolaryn
Received: July 29, 2025
Revised: September 3, 2025
Accepted: October 23, 2025
Published online: November 26, 2025
Processing time: 115 Days and 23.8 Hours
Revised: September 3, 2025
Accepted: October 23, 2025
Published online: November 26, 2025
Processing time: 115 Days and 23.8 Hours
Core Tip
Core Tip: We report a unique case of acquired hemophilia A, an autoimmune bleeding disorder due to factor VIII (FVIII) autoantibodies, occurring after head and neck cancer surgery and chemoradiotherapy—a previously unreported association. A 65-year-old male developed recurrent hemoptysis, diagnosed by prolonged activated partial thromboplastin time and high-titer FVIII inhibitors. Intensive immunosuppressive therapy achieved sustained six-year remission, demonstrating the critical role of timely diagnosis and aggressive management for this severe therapy-related complication.