©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2025; 13(33): 112045
Published online Nov 26, 2025. doi: 10.12998/wjcc.v13.i33.112045
Published online Nov 26, 2025. doi: 10.12998/wjcc.v13.i33.112045
Lipoprotein (a) levels are elevated in psoriasis: An updated systematic review and meta-analysis
Magdalini-Rigina Fragkouli, Christina Mastori-Kourmpani, Nikos Karpettas, Georgios F Hadjigeorgiou, Constantinos Tsioutis, Aris P Agouridis, School of Medicine, European University Cyprus, Nicosia 2404, Cyprus
Anastasios Makris, School of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece
Theodosios D Filippatos, Department of Internal Medicine, School of Medicine, University of Crete, Heraklion 71003, Greece
Author contributions: Fragkouli MR and Agouridis AP conceptualized and designed the study, participated in data acquisition, extraction and interpretation, prepared tables, wrote and drafted the initial manuscript and approved the final manuscript as submitted; Makris A, Mastori-Kourmpani C, Karpettas N, Hadjigeorgiou GF, Tsioutis C, and Filippatos TD reviewed and revised the manuscript and approved the final manuscript as submitted; all authors have read and agreed to the published version of the manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest. The study was conducted independently without external funding.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Theodosios D Filippatos, MD, PhD, Associate Professor, Department of Internal Medicine, School of Medicine, University of Crete, Panepistimiou Ave, Heraklion 71003, Greece. filtheo@uoc.gr
Received: July 16, 2025
Revised: July 23, 2025
Accepted: October 28, 2025
Published online: November 26, 2025
Processing time: 128 Days and 8.9 Hours
Revised: July 23, 2025
Accepted: October 28, 2025
Published online: November 26, 2025
Processing time: 128 Days and 8.9 Hours
Core Tip
Core Tip: Elevated lipoprotein (a) [Lp(a)] levels represent an atherosclerotic cardiovascular disease risk (ASCVD) factor. The findings of the present systematic review and meta-analysis show a significant increase of Lp(a) levels in psoriasis patients compared with healthy controls. As such, Lp(a) measurement in patients with psoriasis may be of use for a more precise determination of ASCVD risk and treatment goals.