Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2025; 13(27): 107704
Published online Sep 26, 2025. doi: 10.12998/wjcc.v13.i27.107704
Enterococcal autoprobiotics in the complex treatment of colorectal cancer patient receiving chemotherapy: Two case reports and review of literature
Elena I Ermolenko, Natalia V Baryshnikova, Sergei A Kovalis, Nadezhda S Novilova, Victoria V Orlova, Anastasia S Ilyina, Victor A Kashchenko, Galina F Leontieva, Alexander N Suvorov
Elena I Ermolenko, Natalia V Baryshnikova, Nadezhda S Novilova, Victoria V Orlova, Galina F Leontieva, Alexander N Suvorov, Department of Molecular Microbiology, Institute of Experimental Medicine, St. Petersburg 197376, Russia
Natalia V Baryshnikova, Department of Internal Diseases of Stomatologic Faculty, Pavlov First St. Petersburg State Medical University, St-Petersburg 197022, Russia
Natalia V Baryshnikova, Laboratory of Medico-social Pediatric Problems, St-Petersburg State Pediatric Medical University, St-Petersburg 194100, Russia
Sergei A Kovalis, Anastasia S Ilyina, Department of Chemotherapy, North-Western District Scientific and Clinical Center Named after L. G. Sokolov, St-Petersburg 194291, Russia
Anastasia S Ilyina, Department of Clinical, Institute of Experimental Medicine, St. Petersburg 197376, Russia
Victor A Kashchenko, Head of the Department of Faculty Surgery, St. Petersburg State University Medical Institute, St. Petersburg 190000, Russia
Author contributions: Baryshnikova NV and Ermolenko EI contributed to conceptualization, validation, formal analysis; Kashchenko VA, Baryshnikova NV and Ermolenko EI contributed to methodology; Novilova NS, Orlova VV and Ilyina AS contributed to resources; Leontieva GF, Baryshnikova NV and Ermolenko EI contributed to data curation; Suvorov AN, Kashchenko VA and Ermolenko EI contributed to project administration, supervision; All authors have read and agreed to the published version of the manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Natalia V Baryshnikova, MD, PhD, Associate Professor, Department of Molecular Microbiology, Institute of Experimental Medicine, Pavlova, 12A, St. Petersburg 197376, Russia. baryshnikova_nv@mail.ru
Received: March 28, 2025
Revised: April 23, 2025
Accepted: June 24, 2025
Published online: September 26, 2025
Processing time: 130 Days and 18.2 Hours
Core Tip

Core Tip: The use of individualized autoprobiotic strains of indigenous enterococci can be recommended for postoperative colorectal cancer (CRC) patients undergoing chemotherapy to reduce the risk of postoperative complications, enhance treatment efficacy and tolerability, and improve overall quality of life. Moreover, restoring gut microbiota homeostasis may help lower the risk of CRC recurrence by reducing pro-carcinogenic inflammation associated with gut dysbiosis.