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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 6, 2025; 13(25): 108244
Published online Sep 6, 2025. doi: 10.12998/wjcc.v13.i25.108244
Published online Sep 6, 2025. doi: 10.12998/wjcc.v13.i25.108244
Effects of herbal medicines containing Paeoniae Radix on patients with restless legs syndrome: A retrospective chart review study
Young Seon Lee, Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, South Korea
Han-Gyul Lee, Seungwon Kwon, Woo-Sang Jung, Sang-Kwan Moon, Department of Cardiology and Neurology, Kyung Hee University College of Korean Medicine, Kyung Hee University Medical Center, Seoul 02447, South Korea
Seung-Yeon Cho, Seong-Uk Park, Jung-Mi Park, Chang-Nam Ko, Stroke and Neurological Disorders Center, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul 05278, South Korea
Co-first authors: Young Seon Lee and Han-Gyul Lee.
Author contributions: Lee YS and Lee HG wrote the outline as co-first authors; Kwon S was responsible for the conception, supervision and design of the study as co-corresponding authors; Lee YS, Lee HG, Jung WS and Kwon S did the research and data curating; Lee YS, Lee HG, Cho SY, Jung WS, Park SW, Moon SK, Park JM and Ko CN assisted in the draft editing and reviewing all version of the manuscript. All authors provided the final approval of the article.
Supported by Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), the Ministry of Health and Welfare, Republic of Korea, No. RS-2023-KH142002.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Kyung Hee University Korean Medicine Hospital (KOMCIRB 2023-01-005, approved on February 27, 2023).
Informed consent statement: Written informed consent was obtained from all participants before the study.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Data sharing statement: sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Seungwon Kwon, MD, DKM, PhD, Doctor of Korean Medicine, Associate Professor, Department of Cardiology and Neurology, Kyung Hee University College of Korean Medicine, Kyung Hee University Medical Center, Kyungheedae-ro 23, Dong
Received: April 10, 2025
Revised: April 25, 2025
Accepted: May 27, 2025
Published online: September 6, 2025
Processing time: 88 Days and 21.7 Hours
Revised: April 25, 2025
Accepted: May 27, 2025
Published online: September 6, 2025
Processing time: 88 Days and 21.7 Hours
Core Tip
Core Tip: Restless legs syndrome (RLS) is a chronic condition, but is difficult to manage due to the limitations associated with the long-term use of conventional treatments. This retrospective chart review study demonstrated that herbal medicine containing Paeoniae Radix (HCP) effectively and safely alleviated RLS symptoms. HCP may serve as a promising alternative therapy for patients with RLS. These findings highlight the potential role of herbal medicine in RLS management.