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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 6, 2025; 13(25): 106335
Published online Sep 6, 2025. doi: 10.12998/wjcc.v13.i25.106335
Published online Sep 6, 2025. doi: 10.12998/wjcc.v13.i25.106335
Different clinical profile of leptospirosis in a tertiary care Indian hospital: A Himalayan experience
Drupad Das, Prasan Kumar Panda, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, Rishikesh 249203, India
Sindura Ponnampurathu, Yogendra Pratap Mathuria, Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, Rishikesh 249203, India
Co-first authors: Drupad Das and Sindura Ponnampurathu.
Author contributions: Das D and Ponnampurathu S contributed to data collection, data analysis and manuscript writing; Panda PK and Mathuria YP provided the concept, interpreted the analysis, critically reviewed the draft, and approved it for publication along with first two authors.
Institutional review board statement: The study was reviewed and approved by the Institutional Ethics Committee, AIIMS Rishikesh to ensure patient confidentiality, data protection, and adherence to ethical standards in research involving human participants.
Informed consent statement: Requirement of informed written consent was waived prior to study enrollment considering the retrospective nature of data collection.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: sharing statement: Data will be made available to others upon request to the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Prasan Kumar Panda, MD, Professor, Department of Internal Medicine, All India Institute of Medical Sciences, Room No. 409, College Block, Rishikesh 249203, India. motherprasanna@rediffmail.com
Received: February 24, 2025
Revised: April 15, 2025
Accepted: May 13, 2025
Published online: September 6, 2025
Processing time: 134 Days and 17.7 Hours
Revised: April 15, 2025
Accepted: May 13, 2025
Published online: September 6, 2025
Processing time: 134 Days and 17.7 Hours
Core Tip
Core Tip: This study highlights the high burden of severe leptospirosis, with significant multiorgan dysfunction, intensive care unit needs, and a 20.97% overall mortality rate. Patients from the Himalayan region had more severe renal impairment, higher hemodialysis requirements, and nearly double the mortality of the Sub-Himalayan group. Jaundice and acute respiratory distress syndrome were potential contributors to mortality, while international normalized ratio showed a possible protective association. These findings emphasize regional variability in disease severity and the need for targeted risk stratification and resource allocation.