Scientometrics
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 6, 2025; 13(10): 101719
Published online Apr 6, 2025. doi: 10.12998/wjcc.v13.i10.101719
Nano-drug delivery systems integrated with low radiation doses for enhanced therapeutic efficacy in cancer treatment
Antonio Pontoriero, Paola Critelli, Marco Zeppieri, Alberto Bosurgi, Stefania Guercio, Maria Caffo, Filippo Flavio Angileri, Silvana Parisi, Salvatore Lavalle, Stefano Pergolizzi
Antonio Pontoriero, Paola Critelli, Alberto Bosurgi, Silvana Parisi, Stefano Pergolizzi, Radiation Oncology Unit, Department of Biomedical, Dental Science and Morphological and Functional Images, University of Messina, Messina 98125, Italy
Marco Zeppieri, Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy
Stefania Guercio, Maria Caffo, Filippo Flavio Angileri, Neurosurgery Unit, Department of Biomedical, Dental Science and Morphological and Functional Images, Messina, Italy, Messina 98125, Italy
Salvatore Lavalle, Department of Medicine and Surgery, University of Enna "Kore", Enna 94100, Italy
Author contributions: Pontoriero A and Critelli P wrote the outline, did the research, wrote the paper; Bosurgi A and Guercio S assisted in the research; Parisi S, Angileri FF assisted in the writing, editing, and making critical revisions, visualization and final approval of the manuscript; Pontoriero A and Pergolizzi S provided the final approval of the article; Zeppieri M assisted in the conception and design of the study, writing, outline, final approval of the version of the article to be published and completed the English and scientific editing.
Conflict-of-interest statement: All authors have no conflict of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marco Zeppieri, MD, PhD, Department of Ophthalmology, University Hospital of Udine, p.le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Received: September 24, 2024
Revised: November 11, 2024
Accepted: December 5, 2024
Published online: April 6, 2025
Processing time: 85 Days and 15.3 Hours
Core Tip

Core Tip: Glioblastoma is a highly aggressive brain cancer, which main treatment consists of surgical resection or biopsy followed by radiotherapy and chemotherapy (STUPP protocol). Precision medicine is an emerging field that includes tumor-targeted delivery and tumor microenvironment. The integration of nano drug delivery systems with low radiation doses may offer a promising avenue for maximizing therapeutic efficacy and minimizing systemic toxicity.