Nano-drug delivery systems integrated with low radiation doses for enhanced therapeutic efficacy in cancer treatment

doi:10.12998/wjcc.v13.i10.101719

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World Journal of Clinical Cases

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World J Clin Cases. Apr 6, 2025; 13(10): 101719
Published online Apr 6, 2025. doi: 10.12998/wjcc.v13.i10.101719

Nano-drug delivery systems integrated with low radiation doses for enhanced therapeutic efficacy in cancer treatment

Antonio Pontoriero, Paola Critelli, Marco Zeppieri, Alberto Bosurgi, Stefania Guercio, Maria Caffo, Filippo Flavio Angileri, Silvana Parisi, Salvatore Lavalle, Stefano Pergolizzi

Antonio Pontoriero, Paola Critelli, Alberto Bosurgi, Silvana Parisi, Stefano Pergolizzi, Radiation Oncology Unit, Department of Biomedical, Dental Science and Morphological and Functional Images, University of Messina, Messina 98125, Italy

Marco Zeppieri, Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy

Stefania Guercio, Maria Caffo, Filippo Flavio Angileri, Neurosurgery Unit, Department of Biomedical, Dental Science and Morphological and Functional Images, Messina, Italy, Messina 98125, Italy

Salvatore Lavalle, Department of Medicine and Surgery, University of Enna "Kore", Enna 94100, Italy

Author contributions: Pontoriero A and Critelli P wrote the outline, did the research, wrote the paper; Bosurgi A and Guercio S assisted in the research; Parisi S, Angileri FF assisted in the writing, editing, and making critical revisions, visualization and final approval of the manuscript; Pontoriero A and Pergolizzi S provided the final approval of the article; Zeppieri M assisted in the conception and design of the study, writing, outline, final approval of the version of the article to be published and completed the English and scientific editing.

Conflict-of-interest statement: All authors have no conflict of interest to declare.

PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.

Corresponding author: Marco Zeppieri, MD, PhD, Department of Ophthalmology, University Hospital of Udine, p.le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it

Received: September 24, 2024
Revised: November 11, 2024
Accepted: December 5, 2024
Published online: April 6, 2025
Processing time: 85 Days and 15.3 Hours

Abstract

BACKGROUND

Precision medicine is an emerging field that includes tumor-targeted delivery and tumor microenvironment. This review explores the synergistic potential of combining nano-drug delivery systems with low radiation doses to achieve optimized therapeutic outcomes, particularly in the context of cancer treatment. Nanoparticle-based drug carriers offer precise and targeted delivery, enhancing the therapeutic index of anticancer agents. The use of lower radiation doses has become a focus in radiation oncology to minimize off-target effects on healthy tissues in palliation treatment with high-target volume lesions.

AIM

To conduct a bibliometric review of nanomedicine and glioblastoma (GBM), all relevant studies from the last two decades were included.

METHODS

The search strategy comprised the keywords ”nanomedicine “and “glioblastoma” in the title and/or abstract. All English-language documents from 1 January 2000 to 31 December 2023 were considered for the analysis. R code (version 4.2.0) with R Studio (version 2022.12.0-353) and the Bibliometrix package (version 4.0.1) were used for the analysis. A total of 680 documents were collected.

RESULTS

We analyzed the bibliometric features of nanomedicine in glioma. With the limitations of the research, our analysis aims to highlight the increasing interest of researchers in the precision medicine field in GBM treatment and lead us to suggest further studies focusing on the association between nanomedicine and radiotherapy.

CONCLUSION

Due to the poor prognosis associated with GBM, new therapeutic approaches are necessary. There is an increasing interest in precision medicine, which includes nanomedicine and radiotherapy, for GBM treatment. This integration enhances the efficacy of targeted treatments and provides a promising avenue for reducing adverse effects, signifying a notable advancement in precision oncology.

Keywords: Nanomedicine; Nanoparticles; Drug-delivery; Radiotherapy; Combination therapy

Core Tip: Glioblastoma is a highly aggressive brain cancer, which main treatment consists of surgical resection or biopsy followed by radiotherapy and chemotherapy (STUPP protocol). Precision medicine is an emerging field that includes tumor-targeted delivery and tumor microenvironment. The integration of nano drug delivery systems with low radiation doses may offer a promising avenue for maximizing therapeutic efficacy and minimizing systemic toxicity.