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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 6, 2023; 11(13): 2934-2944
Published online May 6, 2023. doi: 10.12998/wjcc.v11.i13.2934
Published online May 6, 2023. doi: 10.12998/wjcc.v11.i13.2934
Association of C-reactive protein and complement factor H gene polymorphisms with risk of lupus nephritis in Chinese population
Qiu-Yu Li, Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China
Jian-Min Lv, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Xiao-Ling Liu, School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China
Hai-Yun Li, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Feng Yu, Department of Medicine, Peking University First Hospital, Beijing 100034, China
Author contributions: Yu F and Li HY designed the research. Li QY, Lv JM, and Liu XL performed the experiments. Lv JM and Li HY analyzed the data and wrote the paper. All authors reviewed and approved the final version of the manuscript.
Institutional review board statement: The work was approved by the Ethics Committee of Peking University First Hospital [Approval No. 2017(1333)].
Informed consent statement: Informed written consent was obtained from the patient and her family for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest with the contents of this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Yun Li, PhD, Assistant Professor, School of Basic Medical Sciences, Xi’an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi Province, China. lihaiy@xjtu.edu.cn
Received: September 16, 2022
Peer-review started: September 16, 2022
First decision: October 11, 2022
Revised: October 25, 2023
Accepted: February 21, 2023
Article in press: February 21, 2023
Published online: May 6, 2023
Processing time: 220 Days and 22.8 Hours
Peer-review started: September 16, 2022
First decision: October 11, 2022
Revised: October 25, 2023
Accepted: February 21, 2023
Article in press: February 21, 2023
Published online: May 6, 2023
Processing time: 220 Days and 22.8 Hours
Core Tip
Core Tip: In spite of the unambiguous pathogenic roles of C-reactive protein (CRP)and complement factor H (CFH) in lupus nephritis (LN), our present study involving a Chinese population has failed to reveal any significant associations of their genetic variations with LN risk. These findings suggest that most genetic variations of CRP and CFH might possess limited biological effects on their expressions or activities and are thus not sufficient to influence the disease course of LN. Overall, we concluded that genetic variations of CRP and CFH could not be used to improve the risk stratification of LN in Chinese population.