Association of C-reactive protein and complement factor H gene polymorphisms with risk of lupus nephritis in Chinese population

doi:10.12998/wjcc.v11.i13.2934

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World Journal of Clinical Cases

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Case Control Study

World J Clin Cases. May 6, 2023; 11(13): 2934-2944
Published online May 6, 2023. doi: 10.12998/wjcc.v11.i13.2934

Association of C-reactive protein and complement factor H gene polymorphisms with risk of lupus nephritis in Chinese population

Qiu-Yu Li, Jian-Min Lv, Xiao-Ling Liu, Hai-Yun Li, Feng Yu

Qiu-Yu Li, Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China

Jian-Min Lv, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China

Xiao-Ling Liu, School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China

Hai-Yun Li, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi'an 710061, Shaanxi Province, China

Feng Yu, Department of Medicine, Peking University First Hospital, Beijing 100034, China

Author contributions: Yu F and Li HY designed the research. Li QY, Lv JM, and Liu XL performed the experiments. Lv JM and Li HY analyzed the data and wrote the paper. All authors reviewed and approved the final version of the manuscript.

Institutional review board statement: The work was approved by the Ethics Committee of Peking University First Hospital [Approval No. 2017(1333)].

Informed consent statement: Informed written consent was obtained from the patient and her family for publication of this report and any accompanying images.

Conflict-of-interest statement: The authors declare that they have no conflicts of interest with the contents of this article.

Data sharing statement: No additional data are available.

STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.

Corresponding author: Hai-Yun Li, PhD, Assistant Professor, School of Basic Medical Sciences, Xi’an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi Province, China. lihaiy@xjtu.edu.cn

Received: September 16, 2022
Peer-review started: September 16, 2022
First decision: October 11, 2022
Revised: October 25, 2023
Accepted: February 21, 2023
Article in press: February 21, 2023
Published online: May 6, 2023
Processing time: 220 Days and 22.8 Hours

Abstract

BACKGROUND

Complement overactivation is a major driver of lupus nephritis (LN). Impaired interactions of C-reactive protein (CRP) with complement factor H (CFH) have been shown as a pathogenic mechanism that contributes to the overactivation of complement in LN. However, genetic variations of neither CRP nor CFH show consistent influences on the risk of LN.

AIM

To examine whether genetic variations of CRP and CFH in combination can improve the risk stratification in Chinese population.

METHODS

We genotyped six CRP single nucleotide polymorphisms (SNPs) (rs1205, rs3093062, rs2794521, rs1800947, rs3093077, and rs1130864) and three CFH SNPs (rs482934, rs1061170, and rs1061147) in 270 LN patients and 303 healthy subjects.

RESULTS

No linkage was found among CRP and CFH SNPs, indicating lack of genetic interactions between the two genes. Moreover, CRP and CFH SNPs, neither individually nor in combination, are associated with the risk or clinical manifestations of LN. Given the unambiguous pathogenic roles of the two genes.

CONCLUSION

These findings suggest that the biological effects of most genetic variations of CRP and CFH on their expressions or activities are not sufficient to influence the disease course of LN.

Keywords: Systemic lupus erythematosus; Lupus nephritis; C-reactive protein; Complement factor H; Single nucleotide polymorphism.

Core Tip: In spite of the unambiguous pathogenic roles of C-reactive protein (CRP)and complement factor H (CFH) in lupus nephritis (LN), our present study involving a Chinese population has failed to reveal any significant associations of their genetic variations with LN risk. These findings suggest that most genetic variations of CRP and CFH might possess limited biological effects on their expressions or activities and are thus not sufficient to influence the disease course of LN. Overall, we concluded that genetic variations of CRP and CFH could not be used to improve the risk stratification of LN in Chinese population.