Zhang C, Jia CJ, Xu C, Sheng QJ, Dou XG, Ding Y. Undifferentiated embryonal sarcoma of the liver: Clinical characteristics and outcomes. World J Clin Cases 2020; 8(20): 4763-4772 [PMID: 33195644 DOI: 10.12998/wjcc.v8.i20.4763]
Corresponding Author of This Article
Yang Ding, PhD, Professor, Department of Infectious Diseases, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang 110022, Liaoning Province, China. yding0903@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Oct 26, 2020; 8(20): 4763-4772 Published online Oct 26, 2020. doi: 10.12998/wjcc.v8.i20.4763
Undifferentiated embryonal sarcoma of the liver: Clinical characteristics and outcomes
Chong Zhang, Chang-Jun Jia, Can Xu, Qiu-Ju Sheng, Xiao-Guang Dou, Yang Ding
Chong Zhang, Qiu-Ju Sheng, Xiao-Guang Dou, Yang Ding, Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang 110022, Liaoning Province, China
Chang-Jun Jia, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110022, Liaoning Province, China
Can Xu, Department of Pathology, Shengjing Hospital of China Medical University, Shenyang 110022, Liaoning Province, China
Author contributions: Zhang C and Ding Y designed and performed the research and wrote the paper; Dou XG designed the research and supervised the report; Sheng QJ contributed to the analysis; Jia CJ and Xu C provided clinical advice; all authors have read and approved the final manuscript.
Supported byThe National Science and Technology Major Project, No. 2017ZX10201201 and No. 2017ZX10202202; and Liaoning Provincial Natural Science Foundation, No. 20180550096.
Institutional review board statement: The study was reviewed and approved by Shengjing Hospital of China Medical University Institutional Review Board (No. 2016PS248K).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yang Ding, PhD, Professor, Department of Infectious Diseases, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang 110022, Liaoning Province, China. yding0903@sina.com
Received: June 28, 2020 Peer-review started: June 28, 2020 First decision: August 8, 2020 Revised: August 20, 2020 Accepted: August 29, 2020 Article in press: August 29, 2020 Published online: October 26, 2020 Processing time: 120 Days and 0.4 Hours
ARTICLE HIGHLIGHTS
Research background
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare liver malignancy originating from primary mesenchymal tissue. The clinical manifestations, laboratory tests, and imaging examinations of the UESL lack specificity and the preoperative misdiagnosis rate is high.
Research motivation
Analyzing the clinical characteristics of UESL, summarizing the diagnostic criteria, and discussing the best treatment scheme are of great significance for the diagnosis and treatment of this malignancy.
Research objectives
The aim of this study was to investigate the diagnosis, treatment, and prognosis of UESL.
Research methods
This study is a single-center retrospective study with a large time span and wide age distribution among the enrolled patients. From 2005 to 2017, we recruited 14 patients with pathologically confirmed UESL. We analyzed the clinical manifestations, laboratory tests, imaging examinations, pathological examinations, therapy, and prognosis of these patients.
Research results
There were nine males and five females aged 2–60 years old included in the study. The major initial symptoms were abdominal pain (71.43%) and fever (57.14%). Preoperative misdiagnosis rate was high, and there was no difference between adults and children. Complete resection was important to improve survival rate.
Research conclusions
Preoperative imaging examination for UESL has a high misdiagnosis rate. Multidisciplinary collaboration can improve the diagnostic accuracy of UESL. Complete surgical resection is the first choice for treatment of UESL.
Research perspectives
The standards and efficacy of comprehensive treatment need to be further investigated.
