Sarver J, Baydoun A, Gudziak M. Undifferentiated testicular pleomorphic sarcoma: A case report. World J Clin Cases 2026; 14(6): 118138 [DOI: 10.12998/wjcc.v14.i6.118138]
Corresponding Author of This Article
Jordan Sarver, Department of Urology, Detroit Medical Center, Harper Professional Building 4160 John R St. Suite 1017, Detroit, MI 48201, United States. j.sarver1011@gmail.com
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Urology & Nephrology
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Case Report
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Feb 26, 2026 (publication date) through Feb 13, 2026
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Publication Name
World Journal of Clinical Cases
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2307-8960
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Sarver J, Baydoun A, Gudziak M. Undifferentiated testicular pleomorphic sarcoma: A case report. World J Clin Cases 2026; 14(6): 118138 [DOI: 10.12998/wjcc.v14.i6.118138]
World J Clin Cases. Feb 26, 2026; 14(6): 118138 Published online Feb 26, 2026. doi: 10.12998/wjcc.v14.i6.118138
Undifferentiated testicular pleomorphic sarcoma: A case report
Jordan Sarver, Ali Baydoun, Marko Gudziak
Jordan Sarver, Ali Baydoun, Department of Urology, Detroit Medical Center, Detroit, MI 48201, United States
Marko Gudziak, Department of Urology, Michigan Institute of Urology, Pontiac, MI 48341, United States
Author contributions: Sarver J, Baydoun A, and Gudziak M performed the research, contributed ideas, analyzed the data, and wrote the manuscript; Sarver J revised the manuscript. All authors have read and approved the final manuscript.
Informed consent statement: The patient signed an informed consent statement.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Jordan Sarver, Department of Urology, Detroit Medical Center, Harper Professional Building 4160 John R St. Suite 1017, Detroit, MI 48201, United States. j.sarver1011@gmail.com
Received: December 25, 2025 Revised: January 11, 2026 Accepted: February 4, 2026 Published online: February 26, 2026 Processing time: 51 Days and 1.1 Hours
Abstract
BACKGROUND
Genitourinary sarcomas include testicular sarcomas and are the most common subtype of sarcoma within the genitourinary system. Undifferentiated pleomorphic sarcoma is a subtype of soft tissue sarcomas that may affect the extremities and retroperitoneum. However, the presence within the testicle is rare. Here, we present a case of an undifferentiated testicular pleomorphic sarcoma, which will explore the presentation and treatment of a rare type of testicular cancer.
CASE SUMMARY
Here we present a 56-year-old male who comes to the urology clinic for left testicular swelling. The patient then underwent left radical orchiectomy via an inguinal approach for a left testicular mass seen on examination and on scrotal ultrasound. Pathology revealed undifferentiated pleomorphic sarcoma (Federation of the French Cancer Centres grade 3), 9.5 cm in size, and it was limited to the testicle. The surgical margins were negative. A follow-up positron emission tomography computed tomography scan was obtained, which showed no evidence of hypermetabolic lymph nodes or masses in the abdomen or pelvis.
CONCLUSION
Testicular sarcomas are a rare type of soft tissue sarcoma. The standard treatment of the testicular mass usually begins with radical inguinal orchiectomy. Patients with scrotal sarcomas are at high risk of local and distant recurrence, emphasizing the importance of surgical excision and wide margins. There is little studied regarding the integration of radiotherapy and chemotherapy for these cases as neoadjuvant or adjuvant therapies. This case highlights the presentation and treatment of a patient with a rare phenotype of testicular pleomorphic sarcoma treated by radical inguinal orchiectomy. In this study, our patient continued without nodal or distant disease in his initial positron emission tomography computed tomography scan after surgery.
Core Tip: Testicular sarcomas are a rare type of soft tissue sarcoma. The standard treatment of the testicular mass usually begins with radical inguinal orchiectomy. Patients with scrotal sarcomas are at high risk of local and distant recurrence, emphasizing the importance of surgical excision and wide margins. There is little studied regarding the integration of radiotherapy and chemotherapy for these cases as neoadjuvant or adjuvant therapies. This case highlights the presentation and treatment of a patient with a rare phenotype of testicular pleomorphic sarcoma treated by radical inguinal orchiectomy.
