Li HL. Bipolar disorder with multiple comorbidities of a 55-year-old female patient: A case report. World J Clin Cases 2026; 14(10): 118579 [DOI: 10.12998/wjcc.v14.i10.118579]
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Apr 6, 2026 (publication date) through Apr 8, 2026
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Journal Information of This Article
Publication Name
World Journal of Clinical Cases
ISSN
2307-8960
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Li HL. Bipolar disorder with multiple comorbidities of a 55-year-old female patient: A case report. World J Clin Cases 2026; 14(10): 118579 [DOI: 10.12998/wjcc.v14.i10.118579]
Author contributions: Li HL participated in the conceptualization, methodology, data curation, original draft writing, visualization, and formal analysis; Li HL participated in the work, consented to its submission to the journal, and authorized the latest report.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Received: January 6, 2026 Revised: February 7, 2026 Accepted: March 12, 2026 Published online: April 6, 2026 Processing time: 86 Days and 16.7 Hours
Abstract
BACKGROUND
Refractory bipolar disorder (BD), characterized by inadequate response to ≥ 2 mood stabilizers with different mechanisms, presents significant therapeutic challenges. The presence of somatic comorbidities such as hypertension and hypothyroidism further complicates treatment due to pharmacodynamic interactions and heightened suicide risk. This report details a successful multidisciplinary management strategy for a 55-year-old female with 32-year refractory BD, hypertension grade 3, and hypothyroidism, providing clinical insights for similar complex cases.
CASE SUMMARY
A retrospective analysis was conducted on a 55-year-old female patient with a 32-year history of BD, comorbid hypertension grade 3 (extremely high risk) and hypothyroidism. The treatment protocol combined mood stabilizers, atypical antipsychotics, modified electroconvulsive therapy, and cognitive behavioral therapy, with simultaneous optimization of somatic disease management.
CONCLUSION
A comprehensive approach combining “mood stabilizer-based polypharmacy, somatic-psychiatric comorbidity management, and integrated physical/psychological rehabilitation” significantly improves prognosis in refractory BD. Long-term follow-up and family support are critical for relapse prevention.
Core Tip: This report details a successful multidisciplinary management strategy for a 55-year-old female with 32-year refractory bipolar disorder, hypertension grade 3, and hypothyroidism, providing clinical insights for similar complex cases.
