Mirghani HO, Hussien AH. Predictors of intensive care unit admission rates in patients with acute cholangitis. World J Clin Cases 2025; 13(35): 115090 [DOI: 10.12998/wjcc.v13.i35.115090]
Corresponding Author of This Article
Hyder Osman Mirghani, MD, Professor, Department of Internal Medicine, University of Tabuk, Prince Fahd Bin Sulta, Tabuk 51941, Saudi Arabia. s.hyder63@hotmail.com
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Gastroenterology & Hepatology
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Letter to the Editor
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 16, 2025 (publication date) through Dec 16, 2025
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World Journal of Clinical Cases
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2307-8960
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Mirghani HO, Hussien AH. Predictors of intensive care unit admission rates in patients with acute cholangitis. World J Clin Cases 2025; 13(35): 115090 [DOI: 10.12998/wjcc.v13.i35.115090]
World J Clin Cases. Dec 16, 2025; 13(35): 115090 Published online Dec 16, 2025. doi: 10.12998/wjcc.v13.i35.115090
Predictors of intensive care unit admission rates in patients with acute cholangitis
Hyder Osman Mirghani, Abdelwahab H Hussien
Hyder Osman Mirghani, Department of Internal Medicine, University of Tabuk, Tabuk 51941, Saudi Arabia
Abdelwahab H Hussien, Department of Internal Medicine, Faculty of Medicine, University of Tabuk, Tabuk 71491, Saudi Arabia
Author contributions: Mirghani HO conceived and designed the study, conducted the literature search, drafted and made critical revisions to the manuscript, and provided final approval of the version to be published; Hussien AH contributed to drafted and made critical revision.
Conflict-of-interest statement: All authors declare no conflicts of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hyder Osman Mirghani, MD, Professor, Department of Internal Medicine, University of Tabuk, Prince Fahd Bin Sulta, Tabuk 51941, Saudi Arabia. s.hyder63@hotmail.com
Received: October 9, 2025 Revised: October 25, 2025 Accepted: December 3, 2025 Published online: December 16, 2025 Processing time: 69 Days and 23.2 Hours
Abstract
Acute cholangitis (AC) is a heterogeneous disease with considerable variation in clinical presentation and high medical costs. Although the overall mortality rate is decreasing. However, the mortality in severe AC ranged from 10%-30% due to sepsis, multi-organ failure, and systemic inflammatory response syndrome. Assessing the predictors of poor outcomes, including mortality, intensive care unit (ICU) admission, and hospital stay, is vital for early and effective intervention. We assessed the predictors of mortality and ICU admission in patients with AC. We conducted a literature search in PubMed/MEDLINE, Google Scholar, and Cochrane Library for relevant articles. The keywords used were acute cholangitis, biliary cholangitis, predictors, mortality, ICU admission, and Hospital stay. In addition, we assessed the role of early vs late endoscopic retrograde cholangiopancreatography on the outcomes. Old age, end-organ failure, red cell distribution width to albumin ratio, neutrophil-to-lymphocyte ratio, platelet-lymphocyte ratio, the need for ventilator support, diabetes, electrolyte imbalance, procalcitonin-to-albumin ratio, C-reactive protein-to-albumin, Glasgow Coma Scale, and systolic hypertension are predictors of poor outcomes in AC of varying etiology, and concurrent acute pancreatitis was not associated with ICU admission.
Core Tip: Acute cholangitis (AC) is the infection of the bile and bile ducts, usually resulting from obstruction by stones, benign strictures, and malignancies. AC is a heterogeneous disease with considerable variation in clinical presentation and high medical costs. Literature on AC prognosis is scarce, and studies investigating the indicators of admission to intensive care units are needed for the timely introduction of diagnostic measures and treatment. We gave an important insight regarding the independent predictors of mortality and intensive care unit admission.
