Noh BG, Seo HI, Park YM, Oh MH, Song SB. Clinicopathologic differences before and after elective laparoscopic cholecystectomy according to obesity. World J Clin Cases 2025; 13(32): 110391 [DOI: 10.12998/wjcc.v13.i32.110391]
Corresponding Author of This Article
Hyung Il Seo, MD, PhD, Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Yangsan 44955, South Korea. seohi71@hanmail.net
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Surgery
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Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 16, 2025 (publication date) through Nov 15, 2025
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World Journal of Clinical Cases
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Noh BG, Seo HI, Park YM, Oh MH, Song SB. Clinicopathologic differences before and after elective laparoscopic cholecystectomy according to obesity. World J Clin Cases 2025; 13(32): 110391 [DOI: 10.12998/wjcc.v13.i32.110391]
World J Clin Cases. Nov 16, 2025; 13(32): 110391 Published online Nov 16, 2025. doi: 10.12998/wjcc.v13.i32.110391
Clinicopathologic differences before and after elective laparoscopic cholecystectomy according to obesity
Byeong Gwan Noh, Hyung Il Seo, Young Mok Park, Myeong Hun Oh, Su-Bin Song
Byeong Gwan Noh, Myeong Hun Oh, Su-Bin Song, Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan 49241, South Korea
Hyung Il Seo, Young Mok Park, Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Yangsan 44955, South Korea
Author contributions: Noh BG, Seo HI, Park YM, Oh MH, and Song SB contributed to the acquisition of data for this study; Noh BG analyzed the data and wrote the manuscript; Seo HI designed the case. All authors have read and approved the final manuscript.
Supported by Biomedical Research Institute Grant from Pusan National University Hospital, No. 202500360001.
Institutional review board statement: This study was approved by the Pusan National University Hospital Institutional Review Board, No. 2503-019-149.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data that support the findings of this study are available from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hyung Il Seo, MD, PhD, Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Yangsan 44955, South Korea. seohi71@hanmail.net
Received: June 7, 2025 Revised: July 21, 2025 Accepted: September 26, 2025 Published online: November 16, 2025 Processing time: 160 Days and 7.4 Hours
Abstract
BACKGROUND
Although obesity is a well-established contributor to surgical risks, evidence regarding the specific outcomes of laparoscopic cholecystectomy (LC) in obese patients remains scarce.
AIM
To assess clinicopathologic differences and 1-year outcomes following elective LC in patients with obesity and gallstone disease.
METHODS
This retrospective study analyzed data from 65 patients who underwent elective LC for gallstone disease between January 2020 and May 2022, with outcomes assessed at the 1-year follow-up. Patients were categorized as obese (body mass index ≥ 25 kg/m2) or non-obese (body mass index < 25 kg/m2), and comparisons were made across preoperative laboratory values, intraoperative parameters, and patient-reported outcomes.
RESULTS
The obese group had significantly higher American Society of Anesthesiologists scores, higher glycated hemoglobin levels, and lower vitamin D levels than the non-obese group. Elevated triglycerides were more frequent in the obese group, whereas higher high-density lipoprotein levels were more common in the non-obese group. Intraoperative and postoperative outcomes did not differ between the groups. At the 1-year follow-up, 24.6% of patients reported post-cholecystectomy symptoms, with no group differences.
CONCLUSION
Obese patients had higher American Society of Anesthesiologists scores, lower vitamin D, and elevated triglycerides preoperatively, but these differences did not significantly affect intraoperative findings or 1-year postoperative outcomes compared to non-obese patients.
Core Tip: This study investigated the impact of obesity on the clinical characteristics and outcomes of patients undergoing elective laparoscopic cholecystectomy for gallstone disease. Obese patients showed distinct preoperative features, including higher American Society of Anesthesiologists scores, elevated glycated hemoglobin levels, and lower vitamin D levels; however, surgical outcomes were similar to those of non-obese patients. Postoperative care should focus on addressing obesity-related risks to improve long-term outcomes even when immediate surgical results are unaffected.
