Tian X, Zhang N, Liu T. Recognizing and addressing the challenges of concomitant cerebrocardiac infarction. World J Clin Cases 2025; 13(31): 108426 [DOI: 10.12998/wjcc.v13.i31.108426]
Corresponding Author of This Article
Tong Liu, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin 300211, China. liutongdoc@126.com
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Cardiac & Cardiovascular Systems
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Editorial
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 6, 2025 (publication date) through Nov 6, 2025
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Publication Name
World Journal of Clinical Cases
ISSN
2307-8960
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Tian X, Zhang N, Liu T. Recognizing and addressing the challenges of concomitant cerebrocardiac infarction. World J Clin Cases 2025; 13(31): 108426 [DOI: 10.12998/wjcc.v13.i31.108426]
Recognizing and addressing the challenges of concomitant cerebrocardiac infarction
Xu Tian, Nan Zhang, Tong Liu
Xu Tian, Nan Zhang, Tong Liu, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China
Co-first authors: Xu Tian and Nan Zhang.
Author contributions: Tian X and Zhang N jointly reviewed the relevant literature and preliminarily completed the manuscript following discussions, and they contributed equally to this article, as the co-first authors of this manuscript; Liu T provided constructive feedback to refine the manuscript, enhancing its overall quality and coherence; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82170327 and No. 82370332; and Tianjin Key Medical Discipline (Specialty) Construction Project, No. TJYXZDXK-029A.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tong Liu, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin 300211, China. liutongdoc@126.com
Received: April 14, 2025 Revised: May 26, 2025 Accepted: August 26, 2025 Published online: November 6, 2025 Processing time: 199 Days and 15.4 Hours
Abstract
In this article, we comment on the article by Zheng et al. This case report shed light on concomitant cerebrocardiac ischemic (CCI) in a 27-year-old male patient, which is defined as a concurrent acute ischemic stroke (AIS) and acute myocardial infarction event. The patient received urgent systemic thrombolysis at the standard dose for AIS and then planned percutaneous coronary intervention was successfully conducted for ST-segment elevation myocardial infarction treatment. Considering the rarity of the comorbidity, the narrow time window for treatment of both AIS and acute myocardial infarction, as well as the complexity and severity of the condition, there are still no guidelines or consensus that have systematically recommended optimal treatment strategies. The successful treatment of this 27-year-old man suggests that urgent thrombolysis followed by planned percutaneous coronary intervention might be an alternative treatment options in the management of concomitant CCI. However, emergency treatment plans need to be developed according to the specific situation of the patients. A number of factors should be considered when making decision, including the location of occlusion of heart and brain, the hemodynamic instability, the ongoing ischemic symptoms, the presence of contraindications to thrombolysis, and the speed of response of cardiologists or neurointerventionists. Future, further research involving multidisciplinary experts, including neurologist, cardiologist, and specialists in critical care medicine is needed to improve the understanding and management of concomitant CCI.
Core Tip: Concomitant cerebrocardiac ischemic is a rare but urgent condition with extremely high mortality. The management of concomitant concomitant cerebrocardiac ischemic has some dilemmas. In the acute phase, the physicians must decide which disease to treat first, which is related to the severity of the heart and brain lesions. In chronic phases, the use of antiplatelet agents and drugs that improve myocardial remodeling remains controversial. The neurologists and cardiologists should make treatment decisions together.
