Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2023; 11(23): 5440-5446
Published online Aug 16, 2023. doi: 10.12998/wjcc.v11.i23.5440
Application effect of phloroglucinol injection in elderly patients with spastic abdominal pain in emergency department
Yu-Fei Liu, Jian Chen
Yu-Fei Liu, Jian Chen, Emergency Medicine Department, Hefei BOE Hospital, Hefei 230000, Anhui Province, China
Author contributions: Liu YF and Chen J contributed equally to this work; Liu YF designed the study; Chen J contributed to the analysis of the manuscript; Liu YF and Chen J involved in the data and writing of this article; and all authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Hefei BOE Hospital.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that there are no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian Chen, Doctor, Associate Chief Physician, Master’s Student, Emergency Medicine Department, Hefei BOE Hospital, Northwest of the Intersection of Dongfang Avenue and Wenzhong Road, Yaohai District, Hefei 230000, Anhui Province, China. 2670260592@qq.com
Received: June 14, 2023
Peer-review started: June 14, 2023
First decision: June 21, 2023
Revised: June 29, 2023
Accepted: July 25, 2023
Article in press: July 25, 2023
Published online: August 16, 2023
Processing time: 62 Days and 22 Hours
Abstract
BACKGROUND

Although norepinephrine injection is commonly used in emergency situations, it is associated with risks for elderly patients with spasmodic liver pain. This study explores the safety and effectiveness of mebendazole injection, an alternative treatment option, for the emergency management of spasmodic abdominal pain, while minimizing adverse reactions, in elderly patients.

AIM

To explore the development of norepinephrine injection and the adverse reactions of this drug in emergency elderly patients with spasmodic liver pain.

METHODS

The control group consisted of 56 elderly patients visiting our hospital from January 2021 to December 2021. After hospital admission, the control group was intravenously administered tolopin. The experimental group consisted of 56 emergency patients with spasmodic abdominal pain who visited our hospital until June 2022. After hospital admission, the experimental group was intravenously administered toloxazole. The two groups were treated for 3 d. The disappearance of clinical symptoms was observed before and after the treatment, and the difference in adverse reactions between the two groups was compared.

RESULTS

The pain of the wife, fire, diarrhea, drowning, and surrounding time disappeared in the experimental group. No statistical difference was observed between the experimental and control groups in visual pain analog scale (VAS) scores before and after the treatment (P > 0.05). The VAS scores of abdominal pain severity after 0.5 h, 1.0 h, and after 6.0 h of treatment were significantly lower for the experimental group than for the control group. After the treatment, the therapeutic effect in the experimental group was higher and statistically significant than that in the control group (P < 0.05). The probability of adverse reactions before the treatment was lower in the experimental group than in the control group.

CONCLUSION

During emergency, mebendazole injection exhibited a good therapeutic value when used for the clinical treatment of elderly patients with spasmodic stomach pain. It accelerated the disappearance of clinical symptoms such as stomach pain, reduced the stomach weight, and improved clinical activity. Reducing and promoting the frequency of high treatment safety with mebendazole injection is worthwhile.

Keywords: M-triophenol injection; Emergency; Spasmodic abdominal pain in the elderly; Abdominal pain disappearance time; Adverse reactions; Therapeutic effect

Core Tip: Mebendazole injection is a safe and effective treatment option for elderly patients with spasmodic abdominal pain in emergency situations. It can accelerate clinical symptom disappearance, reduce the stomach weight, and improve clinical activity. Mebendazole injection can potentially be applied as a valuable treatment option that is safe for use in this vulnerable population.