Dong HQ, Fu XF, Wang MY, Zhu J. Research progress on reactive oxygen species production mechanisms in tumor sonodynamic therapy. World J Clin Cases 2023; 11(22): 5193-5203 [PMID: 37621595 DOI: 10.12998/wjcc.v11.i22.5193]
Corresponding Author of This Article
Jiang Zhu, MD, PhD, Doctor, Professor, Department of Ultrasound, Women's Hospital, Zhejiang University School of Medicine, No. 1 Xueshi Road, Hangzhou 310000, Zhejiang Province, China. zhujiang1046@zju.edu.cn
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
He-Qin Dong, School of Medicine, Shaoxing University, Shaoxin 312000, Zhejiang Province, China
Xiao-Feng Fu, Min-Yan Wang, Jiang Zhu, Department of Ultrasound, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Author contributions: Dong HQ wrote the manuscript; Wang MY and Fu XF contributed equally to this work; Wang MY and Fu XF were mainly responsible for data collection and figure scheduling; Jiang Zhu were responsible for manuscript modification; all authors have read and approve the final manuscript.
Supported bythe National Natural Science Foundation of China, No. 82272004 and No. 81974470, and by the Nature Science Foundation of Zhejiang Province, No. LZ22H180001.
Conflict-of-interest statement: All the authors have no conflict-of-interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiang Zhu, MD, PhD, Doctor, Professor, Department of Ultrasound, Women's Hospital, Zhejiang University School of Medicine, No. 1 Xueshi Road, Hangzhou 310000, Zhejiang Province, China. zhujiang1046@zju.edu.cn
Received: March 23, 2023 Peer-review started: March 23, 2023 First decision: April 19, 2023 Revised: April 27, 2023 Accepted: May 22, 2023 Article in press: May 22, 2023 Published online: August 6, 2023 Processing time: 133 Days and 3.7 Hours
Abstract
In recent years, because of the growing desire to improve the noninvasiveness and safety of tumor treatments, sonodynamic therapy has gradually become a popular research topic. However, due to the complexity of the therapeutic process, the relevant mechanisms have not yet been fully elucidated. One of the widely accepted possibilities involves the effect of reactive oxygen species. In this review, the mechanism of reactive oxygen species production by sonodynamic therapy (SDT) and ways to enhance the sonodynamic production of reactive oxygen species are reviewed. Then, the clinical application and limitations of SDT are discussed. In conclusion, current research on sonodynamic therapy should focus on the development of sonosensitizers that efficiently produce active oxygen, exhibit biological safety, and promote the clinical transformation of sonodynamic therapy.
Core Tip: This review mainly describes the mechanism of reactive oxygen species generation by sonodynamic therapy and enhances the efficiency of reactive oxygen species generation by improving hypoxia to increase the efficacy of sonodynamic therapy on tumor, and finally summarizes the clinical applications and prospects of sonodynamic therapy.
