Published online Aug 26, 2022. doi: 10.12998/wjcc.v10.i24.8782
Peer-review started: April 14, 2022
First decision: May 31, 2022
Revised: June 12, 2022
Accepted: July 20, 2022
Article in press: July 20, 2022
Published online: August 26, 2022
Processing time: 123 Days and 19.8 Hours
Cervical squamous cell carcinoma (SCC) is the most common type of cervical carcinoma and is generally derived from a precancerous stage called cervical high-grade squamous intraepithelial lesion (HSIL). Usually, the cancer metasta
A 57-year-old postmenopausal woman visited our department and requested a routine cervical check-up. Four years ago, she had undergone a cervical loop electrosurgical excision procedure because of HSIL found during the gynecological examination, and she had not been checked again since. This time, a relapse of the cervical HSIL was diagnosed along with uterine pyometra and endometrial polyps. After 2 wk of antibiotic treatment, a laparoscopic hysterectomy was performed, and the final pathological examination revealed that the cervical HSIL had spread directly upward into the uterine cavity, gradually developing into cervical SCC in the endometrium.
Cervical HSIL/SCC can directly spread upward into the uterus with the most common symptoms of pyometra and cervical stenosis. More attention should be given to the early detection and prevention of this disease.
Core Tip: Under unique circumstances, cervical cancer or precancerous lesions can spread directly upward into the uterine cavity, forming endometrial squamous cell carcinoma, which may alter staging and affect prognosis. Emphasis should be placed on prevention as well as early diagnosis, and although a gynecological ultrasound and an endometrial biopsy may help, their impact is still limited. It is imperative to explore the best clinical strategies for treating this disease.