Weng CY, Ye C, Fan YH, Lv B, Zhang CL, Li M. CD8-positive indolent T-Cell lymphoproliferative disorder of the gastrointestinal tract: A case report and review of literature. World J Clin Cases 2022; 10(15): 4971-4984 [PMID: 35801019 DOI: 10.12998/wjcc.v10.i15.4971]
Corresponding Author of This Article
Meng Li, Doctor, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Street, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. lemon20050928@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. May 26, 2022; 10(15): 4971-4984 Published online May 26, 2022. doi: 10.12998/wjcc.v10.i15.4971
CD8-positive indolent T-Cell lymphoproliferative disorder of the gastrointestinal tract: A case report and review of literature
Chun-Yan Weng, Cheng Ye, Yi-Hong Fan, Bin Lv, Chun-Li Zhang, Meng Li
Chun-Yan Weng, Department of Gastroenterology, The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Cheng Ye, Yi-Hong Fan, Bin Lv, Meng Li, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China
Chun-Li Zhang, Department of Pathology, The First Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou 310006, Zhejiang Province, China
Author contributions: Weng CY, Fan YH reviewed the case; Li M and Weng CY wrote the manuscript; Lv B and Zhang CL edited the manuscript; all authors contributed to discussions and gave final approval of the submitted manuscript.
Informed consent statement: Written informed consent for publication of clinical details and/or clinical images was obtained from the patient. A copy of the consent form is available for review by the Editor of this journal.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Meng Li, Doctor, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Street, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. lemon20050928@163.com
Received: October 21, 2021 Peer-review started: October 21, 2021 First decision: December 1, 2021 Revised: December 13, 2021 Accepted: April 3, 2022 Article in press: April 3, 2022 Published online: May 26, 2022 Processing time: 215 Days and 8.9 Hours
Abstract
BACKGROUND
Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (ITLPD-GI), a primary tumor forming in the gastrointestinal (GI) tract, represents a rarely diagnosed clonal T-cell disease with a protracted clinical course.
CASE SUMMARY
This report presented a 45-year-old male patient with a 6-year history of anal fistula and a more than 10-year history of recurrent diarrhea who was not correctly diagnosed until the occurrence of complications such as intestinal perforation. Postsurgical histopathological analysis, combined with hematoxylin-eosin staining, immunohistochemistry and TCRβ/γ clonal gene rearrangement test, confirmed the diagnosis of CD8+ ITLPD-GI.
CONCLUSION
Individuals with this scarce lymphoma frequently show non-specific symptoms that are hard to recognize. So far, indolent CD8+ ITLPD-GI has not been comprehensively examined. The current mini-review focused on evaluating indolent CD8+ ITLPD-GI cases based on existing literature and discussing future directions for improved differential diagnosis, detection of genetic and epigenetic alterations, and therapeutic target identification.
Core Tip: Here we presented a case report of a patient with a history of anal fistula and chronic recurrent diarrhea. This case was easily misdiagnosed as inflammatory bowel disease, enteropathy associated T-cell lymphoma and other diseases due to the lack of characteristic manifestations, which posed great challenges to clinicians and pathologists.
