Published online Apr 26, 2022. doi: 10.12998/wjcc.v10.i12.3686
Peer-review started: May 31, 2021
First decision: July 1, 2021
Revised: September 14, 2021
Accepted: March 4, 2022
Article in press: March 4, 2022
Published online: April 26, 2022
Processing time: 324 Days and 12.1 Hours
The role of multidetector computed tomography (MDCT) in patients with acute infectious colitis is still unclear.
To examine the usefulness of MDCT in distinguishing the etiology of acute infectious colitis.
Overall, 244 patients who met the criteria for acute infectious colitis and visited the Hospital from February 2015 to 2018 were retrospectively enrolled and divided into two groups (bacterial: 204, viral: 40) according to causes of acute colitis, based on stool PCR. Eleven MDCT parameters, including wall thickening, submucosal edema, mucosal enhancement, serosa involvement, empty colon sign, small bowel involvement, comb sign, continuous distribution, accordion sign, mucosal thickening, and lymph node enlargement, were constructed in a blinded fashion.
MDCT parameters of wall thickening (OR: 13.60; 95%CI: 5.80–31.88; P < 0.001), submucosal edema (OR: 36.08; 95%CI: 13.54–96.13; P < 0.001), mucosal enhancement (OR: 22.55; 95%CI: 9.28–54.81; P < 0.001), serosal involvement (OR: 14.50; 95%CI: 3.33–63.23; P < 0.001), empty colon sign (OR: 6.68; 95%CI: 2.44–18.32; P < 0.001), continuous distribution (OR: 24.09; 95%CI: 9.38–61.90; P < 0.001), accordion sign (OR: 9.02; 95%CI: 1.12–72.35; P = 0.038), mucosal thickening (OR: 46.41; 95%CI: 10.38–207.51; P < 0.001), and lymph node enlargement (OR: 4.39; 95%CI: 1.22–15.72; P = 0.023) were significantly associated with bacterial colitis. At least one positive finding in four CT outcomes (submucosal edema, mucosal enhancement, continuous distribution, mucosal thickening) in summer showed a high probability of bacterial colitis (sensitivity, 41.67; specificity, 92.50; OR: 24.95).
MDCT provides many clues that can be useful in suggesting a specific etiology of acute infectious colitis.
Core Tip: The main purpose of this study was to investigate if computed tomography (CT) is valuable in discriminating bacterial colitis from viral colitis. Multidetector CT (MDCT) parameters of wall thickening, submucosal edema, mucosal enhancement, serosal involvement, empty colon sign, continuous distribution, accordion sign, mucosal thickening, and lymph node enlargement may be suggestive of bacterial colitis. At least one positive finding in four MDCT parameters (submucosal edema, mucosal enhancement, continuous distribution, mucosal thickening) in the summer season is suggestive of a bacterial infection.