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World J Virol. Mar 25, 2026; 15(1): 118602
Published online Mar 25, 2026. doi: 10.5501/wjv.v15.i1.118602
Published online Mar 25, 2026. doi: 10.5501/wjv.v15.i1.118602
Study of extended-spectrum beta-lactamases and AmpC beta-lactamases producing Klebsiella from clinical samples in tertiary care hospital of Punjab
Harpreet Kaur, Shilpa Arora, Vishal Sharma, Kirandeep Kaur, Shivani Kamboj, Department of Microbiology, Guru Gobind Singh Medical College and Hospital, Faridkot 151203, Punjab, India
Author contributions: Kaur H contributed to design, literature search, clinical validation, experiments, statistical analysis, manuscript preparation; Kaur H, Arora S, Sharma V, Kaur K, and Kamboj S contributed towards concepts, clinical study, data analysis, manuscript review, and editing. All authors have read and approved the final manuscript.
Institutional review board statement: The study was initiated after obtaining approval from the Institutional Ethics Committee of G.G.S. Medical College and Hospital, Faridkot.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data supporting this study are not publicly available due to institutional restrictions and confidentiality agreements. Data sharing is subject to ethical approval and restrictions to protect participant confidentiality.
Corresponding author: Harpreet Kaur, MD, Department of Microbiology, Guru Gobind Singh Medical College and Hospital, Sadiq Road, Faridkot 151203, Punjab, India.
Received: January 7, 2026
Revised: January 27, 2026
Accepted: March 9, 2026
Published online: March 25, 2026
Processing time: 65 Days and 20.3 Hours
Revised: January 27, 2026
Accepted: March 9, 2026
Published online: March 25, 2026
Processing time: 65 Days and 20.3 Hours
Core Tip
Core Tip: This study highlights the high prevalence of multidrug-resistant Klebsiella species in a tertiary care hospital, with 59.2% producing ESBL and 47.7% AmpC beta-lactamases. Co-production of both enzymes was observed in 26.9% of isolates, highlighting the urgent need for routine surveillance, phenotypic confirmation, and stringent infection control measures to guide targeted antimicrobial therapy and curb the spread of resistant strains. These findings provide critical insights for clinicians and microbiologists aiming to combat nosocomial Klebsiella infections effectively.