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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jan 19, 2026; 16(1): 110875
Published online Jan 19, 2026. doi: 10.5498/wjp.v16.i1.110875
Published online Jan 19, 2026. doi: 10.5498/wjp.v16.i1.110875
Analysis the incidence and related risk factors of depression in patients with esophageal cancer combined with bone metastasis
Hao-Jie Shi, Department of Thoracic Surgery, The Fifth People’s Hospital of Huai’an, Huai’an 223300, Jiangsu Province, China
Shi-Chao Huang, Department of Orthopedics, People’s Hospital of Tongshan District, Xuzhou 221100, Jiangsu Province, China
Bing-Wu Wang, Department of Medical Oncology, The General Hospital of XZCMG (The Affiliated No. 2 Hospital of XZMC), Xuzhou 221000, Jiangsu Province, China
Author contributions: Shi HJ performed the research and wrote the manuscript; Huang SC conceived the research and provided guidance; Wang BW analyzed the data; and all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Fifth People’s Hospital of Huai’an, approval No. (2022)-001.
Informed consent statement: All study participants and their legal guardians provided written informed consent before recruitment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shi-Chao Huang, Chief Physician, Department of Orthopedics, People’s Hospital of Tongshan District, No. 267 Huaihai West Road, Quanshan District, Xuzhou 221100, Jiangsu Province, China. hxx20180817@163.com
Received: July 15, 2025
Revised: August 15, 2025
Accepted: October 21, 2025
Published online: January 19, 2026
Processing time: 168 Days and 17.9 Hours
Revised: August 15, 2025
Accepted: October 21, 2025
Published online: January 19, 2026
Processing time: 168 Days and 17.9 Hours
Core Tip
Core Tip: This retrospective study recruited 100 patients with esophageal cancer and bone metastasis, finding 42% had depression (assessed via Beck Depression Inventory-II). Multivariate logistic regression identified five independent risk factors: low monthly per capital household income [odds ratio (OR) = 2.66], low education (OR = 2.46), low social support (OR = 5.10), sleep disorders (OR = 2.79), and elevated high-sensitivity C-reactive protein (OR = 1.31 per unit increase). Targeted interventions for these factors may lower depression risk in this population.