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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Sep 24, 2025; 16(9): 110087
Published online Sep 24, 2025. doi: 10.5306/wjco.v16.i9.110087
Published online Sep 24, 2025. doi: 10.5306/wjco.v16.i9.110087
Anatomical distribution of bone metastases in stage IV breast cancer: According to histological subtype
David Shaked Zari, Rostislav Novak, Or Haviv, Itay Ron, Ben Kaplan, Bana Awad, Doron Norman, David Nikomarov, Department of Orthopedic Surgery, Rambam Medical Center, Haifa 3501115, Israel
David Shaked Zari, Rostislav Novak, Or Haviv, Itay Ron, Ben Kaplan, Bana Awad, Doron Norman, David Nikomarov, Technion Israel Institute of Technology, The Ruth and Bruce Rappaport Faculty of Medicine, Haifa 3501115, Israel
Author contributions: Zari DS designed the research, curated the data, performed formal analysis, and wrote the original draft; Novak R performed the investigation, curated the data, and contributed to writing; Haviv O developed the software, performed validation and visualization, and contributed to writing and editing; Ron I contributed to methodology, project administration, and statistical analysis; Kaplan B curated the data, performed investigation, and contributed to writing and editing; Awad B collected the data, performed formal analysis, and contributed to writing and editing; Norman D contributed to methodology and provided supervision; Nikomarov D performed statistical analysis, validation, supervision, and contributed to writing.
Institutional review board statement: This retrospective cohort study was approved by the Rambam Medical Center’s Institutional Review Board (IRB ID: RMB-0110-22) and was conducted in accordance with the Declaration of Helsinki.
Informed consent statement: Due to the retrospective nature of the study and the use of anonymized data, the ethics committee waived the requirement for informed consent from patients.
Conflict-of-interest statement: The authors declare that they have no conflict of interest related to the publication of this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: This manuscript is original, has not been published, and is not under consideration elsewhere.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: David Shaked Zari, MD, Department of Orthopedic Surgery, Rambam Medical Center, Hallya Hashniya, Haifa 3501115, Israel. shaked.zaki1009@gmail.com
Received: May 29, 2025
Revised: June 24, 2025
Accepted: August 5, 2025
Published online: September 24, 2025
Processing time: 117 Days and 17.6 Hours
Revised: June 24, 2025
Accepted: August 5, 2025
Published online: September 24, 2025
Processing time: 117 Days and 17.6 Hours
Core Tip
Core Tip: This study investigates the anatomical distribution of bone metastases in stage IV breast cancer, stratified by histological subtype. Unlike previous reports focusing on general metastatic trends, our analysis highlights specific skeletal predilections-such as rib involvement in HER2-enriched tumors and scapula/clavicle in triple-negative cases. Despite these patterns, survival outcomes and fracture rates did not significantly differ. These findings support a unified clinical approach while offering new insights that may refine imaging surveillance strategies.