Published online Feb 24, 2025. doi: 10.5306/wjco.v16.i2.99635
Revised: September 24, 2024
Accepted: October 28, 2024
Published online: February 24, 2025
Processing time: 137 Days and 23.2 Hours
Colorectal cancer (CRC) ranks high among the most common types of malignant tumors. The primary cause of cancer-related mortality is metastasis, with lung metastases accounting for 32.9% of all cases of metastatic CRC (MCRC). However, cases of MCRC in the lungs, which present concurrently with primary peripheral lung adenocarcinoma, are exceptionally rare.
This report describes the case of a 52-year-old female patient who, following a colonoscopy, was diagnosed with moderately differentiated adenocarcinoma based on rectal mucosal biopsy findings. A preoperative chest computed tomography scan revealed a ground-glass nodule in the right lung and a small nodule (approximately 0.6 cm in diameter) in the extramural basal segment of the left lower lobe, which suggested multiple lung metastases from rectal cancer. Subsequent treatment and follow-up led to a diagnosis of rectal cancer with left lung metastasis and peripheral adenocarcinoma of the lower lobe of the right lung.
This case report describes the therapeutic journey of a patient with lung me
Core Tip: A 52-year-old female patient was found to have both lung metastases and primary lung adenocarcinoma after rectal cancer surgery. By combining pathology, immunohistochemistry and molecular genetics techniques, we were able to successfully differentiate between the two different tumor types and formulate a personalized treatment plan that included wedge resection of the left lung and partial resection of the right lung. Multidisciplinary collaboration plays an important role in the treatment process and provides a valuable reference for the clinical management of similar cases.