Qin PF, Yang L, Hu JP, Zhang JY. Breast cancer and rectal cancer associated with Lynch syndrome: A case report. World J Clin Oncol 2024; 15(9): 1215-1221 [PMID: 39351452 DOI: 10.5306/wjco.v15.i9.1215]
Corresponding Author of This Article
Jing-Yue Zhang, PhD, Doctor, Department of Laboratory Medicine, The People Hospital of Guigang, No. 1 Zhongshan Middle Road, Guigang 537100, Guangxi Zhuang Autonomous Region, China. zhangjy79@mail2.sysu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Pei-Fang Qin, Ling Yang, Jun-Ping Hu, Jing-Yue Zhang, Department of Laboratory Medicine, The People Hospital of Guigang, Guigang 537100, Guangxi Zhuang Autonomous Region, China
Co-first authors: Pei-Fang Qin and Ling Yang.
Author contributions: All authors contributed to the study conception and design; Qin PF and Yang L were responsible for analyzing data, material preparation, and writing the manuscript; Hu JP was responsible for drawing and data organization; Zhang JY directed the study and modified the article; all authors have read and approved the final manuscript.
Supported byThe Natural Science Foundation from Guangxi, No. 2024GXNSFBA010056; The Guangxi Zhuang Autonomous Region Health Committee Self-Funded Scientific Research, No. Z-R20231938; and The Guangxi Medical University Youth Science Fund Project, No. GXMUYSF202333.
Informed consent statement: The study according to the ethical guidelines of the Helsinki Declaration and was approved by the Human Ethics Committee of the people Hospital of Guigang. Written informed consent was obtained from individual or guardian participants.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
CARE Checklist (2016) statement: The case has been written according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Yue Zhang, PhD, Doctor, Department of Laboratory Medicine, The People Hospital of Guigang, No. 1 Zhongshan Middle Road, Guigang 537100, Guangxi Zhuang Autonomous Region, China. zhangjy79@mail2.sysu.edu.cn
Received: February 4, 2024 Revised: July 28, 2024 Accepted: August 5, 2024 Published online: September 24, 2024 Processing time: 206 Days and 23.6 Hours
Abstract
BACKGROUND
The development mechanisms of Lynch syndrome (LS)-related breast cancer (BC) and rectal cancer are complex and variable, leading to personalized variations in diagnosis and treatment plans.
CASE SUMMARY
This paper presents a comprehensive review of clinical diagnosis and treatment data from a patient with LS-associated BC and rectal cancer. Moreover, screening data and management guidelines, as well as relevant literature on LS, are included in this report. This study summarizes the molecular pathogenesis, clinicopathological features, and screening and management protocols for LS-associated BC and rectal cancer.
CONCLUSION
Implementing early screening, prevention, and timely diagnosis and treatment measures is expected to reduce mitigate the incidence and mortality of LS-related BC and rectal cancer.
Core Tip: Lynch syndrome (LS) is the most common hereditary cancer syndrome and is characterized by a predisposition to a range of cancers, mainly colorectal cancer and endometrial cancer. In this case, a patient suffered from breast cancer 10 years ago and was subsequently diagnosed with rectal cancer, which is different from traditional LS development. Developing methods to diagnosis LS patients and giving their relatives corresponding genetic counselling advice can significantly reduce the incidence of LS-related tumours.
