Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Feb 24, 2024; 15(2): 282-289
Published online Feb 24, 2024. doi: 10.5306/wjco.v15.i2.282
Endoscopic resection for calcifying fibrous tumors of the gastrointestinal tract
Zi-Han Geng, Yan Zhu, Pei-Yao Fu, Yi-Fan Qu, Shi-Yao Chen, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Wen-Zheng Qin, Jian-Wei Hu, Ming-Yan Cai, Li-Qing Yao, Quan-Lin Li, Ping-Hong Zhou
Zi-Han Geng, Yan Zhu, Pei-Yao Fu, Yi-Fan Qu, Shi-Yao Chen, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Wen-Zheng Qin, Jian-Wei Hu, Ming-Yan Cai, Li-Qing Yao, Quan-Lin Li, Ping-Hong Zhou, Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Zi-Han Geng, Yan Zhu, Pei-Yao Fu, Yi-Fan Qu, Shi-Yao Chen, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Wen-Zheng Qin, Jian-Wei Hu, Ming-Yan Cai, Li-Qing Yao, Quan-Lin Li, Ping-Hong Zhou, Shanghai Collaborative Innovation Center of Endoscopy, Shanghai 200032, China
Co-first authors: Zi-Han Geng and Yan Zhu.
Co-corresponding authors: Quan-Lin Li and Ping-Hong Zhou.
Author contributions: Geng ZH contributed to conceptualization, data curation, formal analysis, investigation, methodology, software, validation, visualization, took the lead in writing - original draft and writing - review and editing; Zhu Y contributed to conceptualization, software, writing - original draft, writing - review and editing; Fu PY contributed to conceptualization, software, writing - original draft, took the lead in writing - review and editing; Qu YF contributed to conceptualization and data curation; Chen SY, Zhong YS, Zhang YQ, Chen WF, Qin WZ, Hu JW, Cai MY, and Yao LQ contributed equally to conceptualization; Li QL and Zhou PH contributed equally to conceptualization and supervision.
Supported by the National Key R&D Program of China, No. 2019YFC1315800; National Natural Science Foundation of China, No. 82170555; Shanghai Rising-Star Program, No. 19QA1401900; Major Project of Shanghai Municipal Science and Technology Committee, No. 19441905200; Shanghai Sailing Program of the Shanghai Municipal Science and Technology Committee, No. 19YF1406400; and the 74th General Support of China Postdoctoral Science Foundation, No. 2023M740675.
Institutional review board statement: This study was approved by the Ethics Committee of the Zhongshan Hospital, in accordance with the Declaration of Helsinki (B-2018-222).
Informed consent statement: Informed consent was obtained from all patients.
Conflict-of-interest statement: All authors have no conflicts of interest or financial ties to disclose.
Data sharing statement: The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ping-Hong Zhou, FASGE, MD, Doctor, Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai 200032, China. zhou.pinghong@zs-hospital.sh.cn
Received: November 26, 2023
Peer-review started: November 26, 2023
First decision: December 25, 2023
Revised: December 26, 2023
Accepted: January 24, 2024
Article in press: January 24, 2024
Published online: February 24, 2024
Processing time: 85 Days and 17.5 Hours
Abstract
BACKGROUND

Calcifying fibrous tumors (CFTs) are rare mesenchymal lesions that can occur in various sites throughout the body, including the tubular gastrointestinal (GI) tract.

AIM

To analyze the clinical findings of 36 patients with GI tract CFTs to provide guidance for diagnosis and treatment.

METHODS

This retrospective study included 36 patients diagnosed with CFTs of the GI tract. We collected demographic and clinical information and conducted regular follow-ups to assess for local recurrence.

RESULTS

The stomach was the most commonly involved site, accounting for 72.2% of the 36 CFTs. Endoscopic mucosal resection (n = 1, 2.8%), endoscopic submucosal dissection (n = 14, 38.9%), endoscopic full-thickness resection (n = 16, 44.4%), and submucosal tunneling endoscopic resection (n = 5, 13.9%) were used to resect calcifying fibrous tumors. Overall, 34 (94.4%) CFTs underwent complete endoscopic resections with a mean procedure time of 39.8 ± 29.8 min. The average maximum diameter of the tumors was 10.6 ± 4.3 cm. No complications, such as bleeding or perforation, occurred during an average hospital stay of 2.9 ± 1.2 d. In addition, two patients developed new growth of CFTs near the primary tumor sites, and none of the patients developed distant metastases during the follow-up period.

CONCLUSION

GI tract CFTs are rare and typically benign tumors that can be effectively managed with endoscopic procedures.

Keywords: Endoscopic resection; Calcifying fibrous tumor; Gastrointestinal tract

Core Tip: Calcifying fibrous tumors (CFTs) are rare and benign mesenchymal neoplasms with a low risk of recurrence and are cured by local removal. The treatment of CFTs primarily aims to relieve symptoms, such as intussusception and obstruction. Gastrointestinal calcifying fibrous tumors can be removed using endoscopic procedures.