Alvarez M, Quintero E, Rincon O, Llanos C, Reales R, Guzman I. Novel Kruppel-like factor 11 variant of maturity-onset diabetes of the young type 7: A case report. World J Diabetes 2025; 16(11): 111106 [DOI: 10.4239/wjd.v16.i11.111106]
Corresponding Author of This Article
Mauricio Alvarez, Department of Endocrinology, Hospital of Militar Central, No. 49-02, Tv. 3C, Bogota 110221, Colombia. mauricioalvarez613@gmail.com
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Endocrinology & Metabolism
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Case Report
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 15, 2025 (publication date) through Nov 14, 2025
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World Journal of Diabetes
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1948-9358
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Alvarez M, Quintero E, Rincon O, Llanos C, Reales R, Guzman I. Novel Kruppel-like factor 11 variant of maturity-onset diabetes of the young type 7: A case report. World J Diabetes 2025; 16(11): 111106 [DOI: 10.4239/wjd.v16.i11.111106]
World J Diabetes. Nov 15, 2025; 16(11): 111106 Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.111106
Novel Kruppel-like factor 11 variant of maturity-onset diabetes of the young type 7: A case report
Mauricio Alvarez, Elias Quintero, Oswaldo Rincon, Carlos Llanos, Rawdy Reales, Isaac Guzman
Mauricio Alvarez, Oswaldo Rincon, Isaac Guzman, Department of Endocrinology, Hospital of Militar Central, Bogota 110221, Colombia
Elias Quintero, Internal Medicine Program, Universidad de la Sabana, Chia 250001, Cundinamarca, Colombia
Carlos Llanos, Rawdy Reales, Endocrinology Program, Universidad Militar Nueva Granada, Bogota 110221, Colombia
Author contributions: Alvarez M, Quintero E, Rincon O, Llanos C, Reales R, and Guzman I made substantial contributions to the conception of the work, the drafting of the manuscript, and the critical revision for important intellectual content. All authors have read and approved the final version to be published and agree to be accountable for all aspects of the work.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this case report and any accompanying images. The patient was assured that their identity would be kept confidential.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mauricio Alvarez, Department of Endocrinology, Hospital of Militar Central, No. 49-02, Tv. 3C, Bogota 110221, Colombia. mauricioalvarez613@gmail.com
Received: June 23, 2025 Revised: July 12, 2025 Accepted: September 23, 2025 Published online: November 15, 2025 Processing time: 144 Days and 4.8 Hours
Abstract
BACKGROUND
Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes often misdiagnosed as type 1 or type 2. The MODY7 subtype, attributed to variants in the Kruppel-like factor 11 (KLF11) gene, is exceedingly rare, and its clinical spectrum is not fully characterized. Precise genetic diagnosis is essential for appropriate management but is challenging due to phenotypic overlap with other diabetes types. This case report describes a patient with a novel KLF11 variant, contributing to the understanding of this rare condition and its clinical implications.
CASE SUMMARY
A 50-year-old female with a family history of MODY in her son was initially diagnosed with type 2 diabetes. Due to the family history and a non-obese phenotype, a comprehensive genetic panel for monogenic diabetes was performed. The analysis identified a novel heterozygous missense variant, p.Cys105Phe, in the KLF11 gene, establishing a definitive diagnosis of MODY7. Following this diagnosis, the patient’s treatment was adjusted to include lifestyle modifications, resulting in adequate glycemic control. The patient has since maintained target glycated hemoglobin levels.
CONCLUSION
Monogenic diabetes type MODY7, caused by a mutation in the KLF11 gene, is extremely rare. Although some studies question its existence, compatible cases continue to be diagnosed, given its inclusion in genetic panels for MODY.
Core Tip: Maturity-onset diabetes of the young (MODY), accounting for 1%-5% of all diabetes cases, is a genetic disorder with subtypes defined by specific gene variants. MODY type 7, a rare form (less than 1% of MODY cases), is linked to the KLF11 gene. We report a MODY type 7 case caused by a novel variant (p.Cys105Phe) in Kruppel-like factor 11. Given its low prevalence and overlap with other diabetes types, precise genetic diagnosis is crucial for confirmation, understanding clinical implications, and optimizing patient care.
