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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2025; 16(11): 111106
Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.111106
Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.111106
Novel Kruppel-like factor 11 variant of maturity-onset diabetes of the young type 7: A case report
Mauricio Alvarez, Oswaldo Rincon, Isaac Guzman, Department of Endocrinology, Hospital of Militar Central, Bogota 110221, Colombia
Elias Quintero, Internal Medicine Program, Universidad de la Sabana, Chia 250001, Cundina
Carlos Llanos, Rawdy Reales, Endocrinology Program, Universidad Militar Nueva Granada, Bogota 110221, Colombia
Author contributions: Alvarez M, Quintero E, Rincon O, Llanos C, Reales R, and Guzman I made substantial contributions to the conception of the work, the drafting of the manuscript, and the critical revision for important intellectual content. All authors have read and approved the final version to be published and agree to be accountable for all aspects of the work.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this case report and any accompanying images. The patient was assured that their identity would be kept confidential.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mauricio Alvarez, Department of Endocrinology, Hospital of Militar Central, No. 49-02, Tv. 3C, Bogota 110221, Colombia. mauricioalvarez613@gmail.com
Received: June 23, 2025
Revised: July 12, 2025
Accepted: September 23, 2025
Published online: November 15, 2025
Processing time: 144 Days and 5.2 Hours
Revised: July 12, 2025
Accepted: September 23, 2025
Published online: November 15, 2025
Processing time: 144 Days and 5.2 Hours
Core Tip
Core Tip: Maturity-onset diabetes of the young (MODY), accounting for 1%-5% of all diabetes cases, is a genetic disorder with subtypes defined by specific gene variants. MODY type 7, a rare form (less than 1% of MODY cases), is linked to the KLF11 gene. We report a MODY type 7 case caused by a novel variant (p.Cys105Phe) in Kruppel-like factor 11. Given its low prevalence and overlap with other diabetes types, precise genetic diagnosis is crucial for confirmation, understanding clinical implications, and optimizing patient care.