Clinical prediction of carcinoembryonic antigen combined with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for postoperative survival in colorectal cancer

Table 1 Comparison of clinical data between two patient groups, mean ± SD/n (%)

Clinical data		Survival group (n = 77)	Death group (n = 43)	t/χ2	P value
Gender	Male	42 (54.55)	24 (55.81)	0.018	0.893
	Female	35 (45.45)	19 (44.19)
Age (years)		60.32 ± 6.85	61.02 ± 7.01	0.5313	0.5962
Body mass index (kg/m2)		21.77 ± 1.49	21.65 ± 1.54	0.4179	0.6768
Tumor size (cm)	≤ 5	47 (61.04)	14 (32.56)	8.955	0.003
	> 5	30 (38.96)	29 (67.44)
Tumor location	Colon	39 (50.65)	21 (48.84)	0.036	0.849
	Rectum	38 (49.35)	22 (51.16)
Clinical stage	I-II	31 (40.26)	14 (32.56)	0.698	0.403
	III-IV	46 (59.74)	29(67.44)
Depth of invasion	T1-T2	48 (62.34)	25 (58.14)	0.204	0.651
	T3-T4	29 (37.66)	18 (41.86)
Histological subtype	Adenocarcinoma	35 (45.45)	21 (48.84)	0.127	0.772
	Others	42 (54.55)	22 (51.16)
Distant metastasis	Yes	1 (1.30)	5 (11.63)	4.21	0.040
	No	76 (98.70)	38 (88.37)

Table 2 Comparison of preoperative neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and carcinoembryonic antigen, mean ± SD

Indicator	Survival group (n = 77)	Death group (n = 43)	t/χ2	P value
NLR (%)	2.98 ± 0.57	4.83 ± 1.25	11.11	< 0.0001
PLR (%)	136.26 ± 2.54	162.33 ± 27.67	8.232	< 0.0001
CEA (ng/mL)	12.19 ± 4.51	20.17 ± 5.29	8.722	< 0.0001

NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; CEA: Carcinoembryonic antigen.

Table 3 Multivariate Cox regression analysis of factors affecting postoperative survival in colorectal cancer patients

Factors	β	SE	Wald	OR (95%CI)	P value
Tumor size	0.331	0.348	0.905	1.393 (0.704-2.758)	0.341
Distant metastasis	0.299	0.320	0.873	1.348 (0.720-2.524)	0.350
NLR	0.460	0.143	10.327	1.585 (1.197-2.098)	0.001
PLR	0.021	0.007	8.414	1.021 (1.007-1.036)	0.004
CEA	0.123	0.027	21.163	1.131 (1.073-1.192)	0.000

NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; CEA: Carcinoembryonic antigen; OR: Odds ratio; CI: Confidence interval.

Table 4 Predictive value of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and carcinoembryonic antigen

Indicator	AUC	Optimal cutoff	Youden index	Sensitivity (%)	Specificity (%)	95%CI	P value
NLR	0.896	4.01	0.7284	76.74	96.10	0.828-0.945	< 0.0001
PLR	0.805	141.14	0.7544	76.74	98.70	0.723-0.872	< 0.0001
CEA	0.880	15.49	0.6192	81.40	80.52	0.817-0.923	< 0.0001
Joint detection	0.977		0.9118	97.67	93.51	0.931-0.996	< 0.0001

NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; CEA: Carcinoembryonic antigen; AUC: Area under the curve.